2A3I
Structural and Biochemical Mechanisms for the Specificity of Hormone Binding and Coactivator Assembly by Mineralocorticoid Receptor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Mineralocorticoid receptor | polymer | 253 | 29460.1 | 1 | UniProt (P08235) Pfam (PF00104) In PDB | Homo sapiens (human) | MR |
| 2 | B | Nuclear receptor coactivator 1, residues 1430-1441 | polymer | 12 | 1429.6 | 1 | UniProt (Q15788) In PDB | NCoA-1, Steroid receptor coactivator-1, SRC-1, RIP160, Hin-2 protein | |
| 3 | A | CORTICOSTERONE | non-polymer | 346.5 | 1 | Chemie (C0R) | |||
| 4 | water | water | 18.0 | 160 | Chemie (HOH) |
Sequence modifications
A: 732 - 984 (UniProt: P08235)
| PDB | External Database | Details |
|---|---|---|
| Ser 808 | Cys 808 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 30889.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 346.5 | |
| All* | Total formula weight | 31236.2 |
