2A3I
Structural and Biochemical Mechanisms for the Specificity of Hormone Binding and Coactivator Assembly by Mineralocorticoid Receptor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mineralocorticoid receptor | polymer | 253 | 29460.1 | 1 | UniProt (P08235) Pfam (PF00104) | Homo sapiens (human) | MR |
| 2 | B (B) | Nuclear receptor coactivator 1, residues 1430-1441 | polymer | 12 | 1429.6 | 1 | UniProt (Q15788) | NCoA-1, Steroid receptor coactivator-1, SRC-1, RIP160, Hin-2 protein | |
| 3 | C (A) | CORTICOSTERONE | non-polymer | 346.5 | 1 | Chemie (C0R) PubChem (16758819) PubChem (23955860) PubChem (24867266) PubChem (44308367) PubChem (24939323) PubChem (71211089) PubChem (51414212) PubChem (53314896) PubChem (53393626) PubChem (56615189) PubChem (56622343) PubChem (256277) PubChem (60111547) PubChem (439739) PubChem (439858) PubChem (667425) PubChem (77847229) PubChem (5753) PubChem (6400915) PubChem (6603769) PubChem (117072366) PubChem (10088985) PubChem (10088986) PubChem (12358831) PubChem (139322712) PubChem (124335856) PubChem (124761752) PubChem (124761753) PubChem (124907328) PubChem (129360099) PubChem (132012243) PubChem (132123953) PubChem (134424963) PubChem (134425001) PubChem (134425135) PubChem (157049267) PubChem (163841308) PubChem (166480827) PubChem (166480843) PubChem (173508841) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 160 | Chemie (HOH) |
Sequence modifications
A: 732 - 984 (UniProt: P08235)
| PDB | External Database | Details |
|---|---|---|
| Ser 808 | Cys 808 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 30889.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 346.5 | |
| All* | Total formula weight | 31236.2 |
