2IAE
Crystal structure of a protein phosphatase 2A (PP2A) holoenzyme.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform | polymer | 589 | 65392.4 | 2 | UniProt (Q76MZ3) Pfam (PF02985) Pfam (PF22646) Pfam (PF13646) | Mus musculus (house mouse) | PP2A, subunit A, PR65-alpha isoform, PP2A, subunit A, R1-alpha isoform |
| 2 | B, E (B, E) | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | polymer | 407 | 48186.9 | 2 | UniProt (Q13362) Pfam (PF01603) | Homo sapiens (human) | PP2A, B subunit, B' gamma isoform, PP2A, B subunit, B56 gamma isoform, PP2A, B subunit, PR61 gamma isoform, PP2A, B subunit, R5 gamma isoform, NY-REN-29 antigen |
| 3 | C, F (C, F) | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | polymer | 309 | 35649.2 | 2 | UniProt (P67775) Pfam (PF00149) | Homo sapiens (human) | PP2A-alpha, Replication protein C, RP-C |
| 4 | G, H (M, N) | microcystin-LR | polymer | 7 | 1014.2 | 2 | NOR (NOR00109) BIRD (PRD_000212) | Microcystis aeruginosa | |
| 5 | I, J, K, L (C, F) | MANGANESE (II) ION | non-polymer | 54.9 | 4 | Chemie (MN) |
Sequence modifications
C, F: 1 - 309 (UniProt: P67775)
| PDB | External Database | Details |
|---|---|---|
| Asn 88 | Asp 88 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 300485.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 219.8 | |
| All* | Total formula weight | 300705.1 |
