Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

2IAE

Crystal structure of a protein phosphatase 2A (PP2A) holoenzyme.

Functional Information from GO Data
ChainGOidnamespacecontents
A0000159cellular_componentprotein phosphatase type 2A complex
A0000775cellular_componentchromosome, centromeric region
A0000785cellular_componentchromatin
A0004722molecular_functionprotein serine/threonine phosphatase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005694cellular_componentchromosome
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0007059biological_processchromosome segregation
A0007143biological_processfemale meiotic nuclear division
A0016020cellular_componentmembrane
A0016328cellular_componentlateral plasma membrane
A0019888molecular_functionprotein phosphatase regulator activity
A0030425cellular_componentdendrite
A0035331biological_processnegative regulation of hippo signaling
A0042995cellular_componentcell projection
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0043029biological_processT cell homeostasis
A0045202cellular_componentsynapse
A0046982molecular_functionprotein heterodimerization activity
A0051225biological_processspindle assembly
A0051232biological_processmeiotic spindle elongation
A0051306biological_processmitotic sister chromatid separation
A0051754biological_processmeiotic sister chromatid cohesion, centromeric
A0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0090443cellular_componentFAR/SIN/STRIPAK complex
A0098978cellular_componentglutamatergic synapse
A0160232cellular_componentINTAC complex
A0160240biological_processRNA polymerase II transcription initiation surveillance
A1903538biological_processregulation of meiotic cell cycle process involved in oocyte maturation
A1990405molecular_functionprotein antigen binding
A2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
B0000159cellular_componentprotein phosphatase type 2A complex
B0007165biological_processsignal transduction
B0019888molecular_functionprotein phosphatase regulator activity
C0000159cellular_componentprotein phosphatase type 2A complex
C0000278biological_processmitotic cell cycle
C0000775cellular_componentchromosome, centromeric region
C0000785cellular_componentchromatin
C0000922cellular_componentspindle pole
C0004721molecular_functionphosphoprotein phosphatase activity
C0004722molecular_functionprotein serine/threonine phosphatase activity
C0004725molecular_functionprotein tyrosine phosphatase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005694cellular_componentchromosome
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005886cellular_componentplasma membrane
C0006357biological_processregulation of transcription by RNA polymerase II
C0006366biological_processtranscription by RNA polymerase II
C0006368biological_processtranscription elongation by RNA polymerase II
C0006470biological_processprotein dephosphorylation
C0007498biological_processmesoderm development
C0008287cellular_componentprotein serine/threonine phosphatase complex
C0010288biological_processresponse to lead ion
C0010719biological_processnegative regulation of epithelial to mesenchymal transition
C0015630cellular_componentmicrotubule cytoskeleton
C0016020cellular_componentmembrane
C0016787molecular_functionhydrolase activity
C0031113biological_processregulation of microtubule polymerization
C0035331biological_processnegative regulation of hippo signaling
C0035556biological_processintracellular signal transduction
C0035970biological_processpeptidyl-threonine dephosphorylation
C0040008biological_processregulation of growth
C0043029biological_processT cell homeostasis
C0045121cellular_componentmembrane raft
C0045202cellular_componentsynapse
C0045595biological_processregulation of cell differentiation
C0046872molecular_functionmetal ion binding
C0046982molecular_functionprotein heterodimerization activity
C0048156molecular_functiontau protein binding
C0050811molecular_functionGABA receptor binding
C0051321biological_processmeiotic cell cycle
C0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C0070062cellular_componentextracellular exosome
C0090090biological_processnegative regulation of canonical Wnt signaling pathway
C0090443cellular_componentFAR/SIN/STRIPAK complex
C0097706biological_processvascular endothelial cell response to oscillatory fluid shear stress
C0160232cellular_componentINTAC complex
C0160240biological_processRNA polymerase II transcription initiation surveillance
C0180006molecular_functionRNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
C0180007molecular_functionRNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
C0180008molecular_functionRNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
C1900227biological_processpositive regulation of NLRP3 inflammasome complex assembly
C1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
C2000045biological_processregulation of G1/S transition of mitotic cell cycle
D0000159cellular_componentprotein phosphatase type 2A complex
D0000775cellular_componentchromosome, centromeric region
D0000785cellular_componentchromatin
D0004722molecular_functionprotein serine/threonine phosphatase activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005694cellular_componentchromosome
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0007059biological_processchromosome segregation
D0007143biological_processfemale meiotic nuclear division
D0016020cellular_componentmembrane
D0016328cellular_componentlateral plasma membrane
D0019888molecular_functionprotein phosphatase regulator activity
D0030425cellular_componentdendrite
D0035331biological_processnegative regulation of hippo signaling
D0042995cellular_componentcell projection
D0043005cellular_componentneuron projection
D0043025cellular_componentneuronal cell body
D0043029biological_processT cell homeostasis
D0045202cellular_componentsynapse
D0046982molecular_functionprotein heterodimerization activity
D0051225biological_processspindle assembly
D0051232biological_processmeiotic spindle elongation
D0051306biological_processmitotic sister chromatid separation
D0051754biological_processmeiotic sister chromatid cohesion, centromeric
D0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D0090443cellular_componentFAR/SIN/STRIPAK complex
D0098978cellular_componentglutamatergic synapse
D0160232cellular_componentINTAC complex
D0160240biological_processRNA polymerase II transcription initiation surveillance
D1903538biological_processregulation of meiotic cell cycle process involved in oocyte maturation
D1990405molecular_functionprotein antigen binding
D2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
E0000159cellular_componentprotein phosphatase type 2A complex
E0007165biological_processsignal transduction
E0019888molecular_functionprotein phosphatase regulator activity
F0000159cellular_componentprotein phosphatase type 2A complex
F0000278biological_processmitotic cell cycle
F0000775cellular_componentchromosome, centromeric region
F0000785cellular_componentchromatin
F0000922cellular_componentspindle pole
F0004721molecular_functionphosphoprotein phosphatase activity
F0004722molecular_functionprotein serine/threonine phosphatase activity
F0004725molecular_functionprotein tyrosine phosphatase activity
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005694cellular_componentchromosome
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005829cellular_componentcytosol
F0005856cellular_componentcytoskeleton
F0005886cellular_componentplasma membrane
F0006357biological_processregulation of transcription by RNA polymerase II
F0006366biological_processtranscription by RNA polymerase II
F0006368biological_processtranscription elongation by RNA polymerase II
F0006470biological_processprotein dephosphorylation
F0007498biological_processmesoderm development
F0008287cellular_componentprotein serine/threonine phosphatase complex
F0010288biological_processresponse to lead ion
F0010719biological_processnegative regulation of epithelial to mesenchymal transition
F0015630cellular_componentmicrotubule cytoskeleton
F0016020cellular_componentmembrane
F0016787molecular_functionhydrolase activity
F0031113biological_processregulation of microtubule polymerization
F0035331biological_processnegative regulation of hippo signaling
F0035556biological_processintracellular signal transduction
F0035970biological_processpeptidyl-threonine dephosphorylation
F0040008biological_processregulation of growth
F0043029biological_processT cell homeostasis
F0045121cellular_componentmembrane raft
F0045202cellular_componentsynapse
F0045595biological_processregulation of cell differentiation
F0046872molecular_functionmetal ion binding
F0046982molecular_functionprotein heterodimerization activity
F0048156molecular_functiontau protein binding
F0050811molecular_functionGABA receptor binding
F0051321biological_processmeiotic cell cycle
F0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
F0070062cellular_componentextracellular exosome
F0090090biological_processnegative regulation of canonical Wnt signaling pathway
F0090443cellular_componentFAR/SIN/STRIPAK complex
F0097706biological_processvascular endothelial cell response to oscillatory fluid shear stress
F0160232cellular_componentINTAC complex
F0160240biological_processRNA polymerase II transcription initiation surveillance
F0180006molecular_functionRNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
F0180007molecular_functionRNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
F0180008molecular_functionRNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
F1900227biological_processpositive regulation of NLRP3 inflammasome complex assembly
F1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
F2000045biological_processregulation of G1/S transition of mitotic cell cycle
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MN C 310
ChainResidue
CASP57
CHIS59
CASP85
CHIS241
CMN311

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MN C 311
ChainResidue
CMN310
CASP85
CASN117
CHIS167
CHIS241

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MN F 310
ChainResidue
FASP57
FHIS59
FASP85
FTYR267
FMN311

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MN F 311
ChainResidue
FASP57
FASP85
FASN117
FHIS167
FHIS241
FMN310

site_idAC5
Number of Residues20
DetailsBINDING SITE FOR CHAIN M OF MICROCYSTIN-LR
ChainResidue
BGLU121
BASP123
CARG89
CHIS118
CGLN122
CILE123
CTYR127
CPRO172
CASP175
CVAL189
CPRO190
CHIS191
CTRP200
CPRO213
CARG214
CGLY215
CLEU243
CTYR267
CARG268
CCYS269

site_idAC6
Number of Residues16
DetailsBINDING SITE FOR CHAIN N OF MICROCYSTIN-LR
ChainResidue
EGLU121
FGLN122
FILE123
FTYR127
FPRO172
FASP175
FVAL189
FPRO190
FHIS191
FTRP200
FPRO213
FARG214
FGLY215
FLEU243
FTYR267
FCYS269

Functional Information from PROSITE/UniProt
site_idPS00125
Number of Residues6
DetailsSER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE
ChainResidueDetails
CLEU114-GLU119

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton donor => ECO:0000250|UniProtKB:P36873
ChainResidueDetails
CHIS118
FHIS118

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:38123684, ECO:0007744|PDB:8SO0, ECO:0007744|PDB:8TTB
ChainResidueDetails
CASP57
CHIS59
CASP85
FASP57
FHIS59
FASP85

site_idSWS_FT_FI3
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:17055435, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:33633399, ECO:0000269|PubMed:34762484, ECO:0007744|PDB:7CUN, ECO:0007744|PDB:7K36, ECO:0007744|PDB:7PKS
ChainResidueDetails
CASN117
CHIS167
CHIS241
FASN117
FHIS167
FHIS241

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P67774
ChainResidueDetails
CTYR307
FTYR307

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Leucine methyl ester => ECO:0000269|PubMed:38123684, ECO:0000269|PubMed:8206937, ECO:0007744|PDB:8SO0, ECO:0007744|PDB:8TTB
ChainResidueDetails
CMLL309
FMLL309

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1aui
ChainResidueDetails
CHIS118
CASN88

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1aui
ChainResidueDetails
FHIS118
FASN88

237735

PDB entries from 2025-06-18

PDB statisticsPDBj update infoContact PDBjnumon