29WD
RNA polymerase II initially transcribing complex with a 2-nt RNA and the +1 nucleosome
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (0) | General transcription and DNA repair factor IIH helicase subunit XPB | polymer | 782 | 89404.7 | 1 | UniProt (P19447) | Homo sapiens (human) | TFIIH subunit XPB,Basic transcription factor 2 89 kDa subunit,BTF2 p89,DNA excision repair protein ERCC-3,DNA repair protein complementing XP-B cells,TFIIH basal transcription factor complex 89 kDa subunit,TFIIH p89,Xeroderma pigmentosum group B-complementing protein |
| 2 | B (1) | TFIIH basal transcription factor complex helicase XPD subunit | polymer | 760 | 87021.1 | 1 | UniProt (P18074) | Homo sapiens (human) | Basic transcription factor 2 80 kDa subunit,BTF2 p80,CXPD,DNA excision repair protein ERCC-2,DNA repair protein complementing XP-D cells,TFIIH basal transcription factor complex 80 kDa subunit,TFIIH p80,Xeroderma pigmentosum group D-complementing protein |
| 3 | C (2) | General transcription factor IIH subunit 1 | polymer | 548 | 62116.5 | 1 | UniProt (P32780) | Homo sapiens (human) | Basic transcription factor 2 62 kDa subunit,BTF2 p62,General transcription factor IIH polypeptide 1,TFIIH basal transcription factor complex p62 subunit |
| 4 | D (3) | General transcription factor IIH subunit 4 | polymer | 462 | 52245.2 | 1 | UniProt (Q92759) | Homo sapiens (human) | Basic transcription factor 2 52 kDa subunit,BTF2 p52,General transcription factor IIH polypeptide 4,TFIIH basal transcription factor complex p52 subunit |
| 5 | E (4) | General transcription factor IIH subunit 2 | polymer | 395 | 44482.0 | 1 | UniProt (Q13888) | Homo sapiens (human) | Basic transcription factor 2 44 kDa subunit,BTF2 p44,General transcription factor IIH polypeptide 2,TFIIH basal transcription factor complex p44 subunit |
| 6 | F (5) | General transcription factor IIH subunit 3 | polymer | 308 | 34416.0 | 1 | UniProt (Q13889) | Homo sapiens (human) | Basic transcription factor 2 34 kDa subunit,BTF2 p34,General transcription factor IIH polypeptide 3,TFIIH basal transcription factor complex p34 subunit |
| 7 | G (6) | General transcription factor IIH subunit 5 | polymer | 71 | 8060.4 | 1 | UniProt (Q6ZYL4) | Homo sapiens (human) | General transcription factor IIH polypeptide 5,TFB5 ortholog,TFIIH basal transcription factor complex TTD-A subunit |
| 8 | H (7) | CDK-activating kinase assembly factor MAT1 | polymer | 309 | 35874.0 | 1 | UniProt (P51948) | Homo sapiens (human) | CDK7/cyclin-H assembly factor,Cyclin-G1-interacting protein,Menage a trois,RING finger protein 66,RING finger protein MAT1,p35,p36 |
| 9 | I (8) | Cyclin-dependent kinase 7 | polymer | 346 | 39090.3 | 1 | UniProt (P50613) | Homo sapiens (human) | 39 kDa protein kinase,p39 Mo15,CDK-activating kinase 1,Cell division protein kinase 7,Serine/threonine-protein kinase 1,TFIIH basal transcription factor complex kinase subunit |
| 10 | J (9) | Cyclin-H | polymer | 323 | 37695.5 | 1 | UniProt (P51946) | Homo sapiens (human) | MO15-associated protein,p34,p37 |
| 11 | K (A) | DNA-directed RNA polymerase subunit | polymer | 1984 | 218889.5 | 1 | UniProt (A0A7M4DUC2) | Sus scrofa (pig) | |
| 12 | L (B) | DNA-directed RNA polymerase subunit beta | polymer | 1300 | 147938.6 | 1 | UniProt (I3LGP4) | Sus scrofa (pig) | |
| 13 | M (C) | DNA-directed RNA polymerase II subunit RPB3 | polymer | 275 | 31439.1 | 1 | UniProt (I3LCH3) | Sus scrofa (pig) | |
| 14 | N (D) | RNA polymerase II subunit D | polymer | 184 | 20962.6 | 1 | UniProt (A0A287ADR4) | Sus scrofa (pig) | |
| 15 | O (E) | DNA-directed RNA polymerase II subunit E | polymer | 210 | 24644.3 | 1 | UniProt (I3LSI7) | Sus scrofa (pig) | RPB5 homolog |
| 16 | P (F) | DNA-directed RNA polymerases I, II, and III subunit RPABC2 | polymer | 127 | 14477.0 | 1 | UniProt (A0A8D1KNW4) | Sus scrofa (pig) | |
| 17 | Q (G) | DNA-directed RNA polymerase II subunit RPB7 | polymer | 172 | 19314.3 | 1 | UniProt (A0A4X1VKG7) | Sus scrofa (pig) | |
| 18 | R (H) | DNA-directed RNA polymerases I, II, and III subunit RPABC3 | polymer | 150 | 17162.3 | 1 | UniProt (I3LCB2) | Sus scrofa (pig) | |
| 19 | S (I) | DNA-directed RNA polymerase II subunit RPB9 | polymer | 125 | 14541.2 | 1 | UniProt (P60899) | Sus scrofa (pig) | RNA polymerase II subunit B9,DNA-directed RNA polymerase II subunit I,RNA polymerase II 14.5 kDa subunit,RPB14.5 |
| 20 | T (J) | DNA-directed RNA polymerases I, II, and III subunit RPABC5 | polymer | 67 | 7655.1 | 1 | UniProt (A0A4X1VYD0) | Sus scrofa (pig) | |
| 21 | U (K) | DNA-directed RNA polymerase II subunit RPB11-a | polymer | 117 | 13310.3 | 1 | UniProt (F1RKE4) | Sus scrofa (pig) | |
| 22 | V (L) | RNA polymerase II subunit K | polymer | 58 | 7018.2 | 1 | UniProt (A0A8D0JYF1) | Sus scrofa (pig) | |
| 23 | W (M) | Transcription initiation factor IIB | polymer | 316 | 34877.9 | 1 | UniProt (Q00403) | Homo sapiens (human) | General transcription factor TFIIB,S300-II |
| 24 | X (N) | DNA (227-MER) | polymer | 236 | 72820.3 | 1 | unidentified adenovirus | ||
| 25 | Y (O) | TATA-box-binding protein | polymer | 339 | 37729.9 | 1 | UniProt (P20226) | Homo sapiens (human) | TATA sequence-binding protein,TATA-binding factor,TATA-box factor,Transcription initiation factor TFIID TBP subunit |
| 26 | Z (Q) | General transcription factor IIF subunit 1 | polymer | 517 | 58343.6 | 1 | UniProt (P35269) | Homo sapiens (human) | General transcription factor IIF 74 kDa subunit,Transcription initiation factor IIF subunit alpha,TFIIF-alpha,Transcription initiation factor RAP74 |
| 27 | AA (R) | General transcription factor IIF subunit 2 | polymer | 249 | 28427.3 | 1 | UniProt (P13984) | Homo sapiens (human) | ATP-dependent helicase GTF2F2,General transcription factor IIF 30 kDa subunit,Transcription initiation factor IIF subunit beta,TFIIF-beta,Transcription initiation factor RAP30 |
| 28 | BA (T) | DNA (227-MER) | polymer | 236 | 72931.4 | 1 | unidentified adenovirus | ||
| 29 | CA (U) | Transcription initiation factor IIA subunit 1 | polymer | 376 | 41544.6 | 1 | UniProt (P52655) | Homo sapiens (human) | General transcription factor IIA subunit 1,TFIIAL,Transcription initiation factor TFIIA 42 kDa subunit,TFIIA-42 |
| 30 | DA (V) | Transcription initiation factor IIA subunit 2 | polymer | 109 | 12469.1 | 1 | UniProt (P52657) | Homo sapiens (human) | General transcription factor IIA subunit 2,TFIIA p12 subunit,TFIIA-12,TFIIAS,Transcription initiation factor IIA gamma chain,TFIIA-gamma |
| 31 | EA (W) | General transcription factor IIE subunit 1 | polymer | 439 | 49516.1 | 1 | UniProt (P29083) | Homo sapiens (human) | General transcription factor IIE 56 kDa subunit,Transcription initiation factor IIE subunit alpha,TFIIE-alpha |
| 32 | FA (X) | Transcription initiation factor IIE subunit beta | polymer | 291 | 33106.8 | 1 | UniProt (P29084) | Homo sapiens (human) | TFIIE-beta,General transcription factor IIE subunit 2 |
| 33 | GA, KA (a, e) | Histone H3.2 | polymer | 136 | 15421.1 | 2 | UniProt (P84233) | Xenopus laevis (African clawed frog) | |
| 34 | HA, LA (b, f) | Histone H4 | polymer | 103 | 11394.4 | 2 | UniProt (P62799) | Xenopus laevis (African clawed frog) | |
| 35 | IA, MA (c, g) | Histone H2A type 1 | polymer | 130 | 14093.4 | 2 | UniProt (P06897) | Xenopus laevis (African clawed frog) | |
| 36 | JA, NA (d, h) | Histone H2B 1.1 | polymer | 126 | 13965.3 | 2 | UniProt (P02281) | Xenopus laevis (African clawed frog) | H2B1.1 |
| 37 | OA (0) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 38 | PA, RB (0, A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 39 | QA (0) | BERYLLIUM TRIFLUORIDE ION | non-polymer | 66.0 | 1 | Chemie (BEF) | |||
| 40 | AB, BB, CB, DB, DC... (0, N, T, 2, W...) | UNKNOWN | non-polymer | 103.1 | 27 | Chemie (UNK) PubChem (80283) | |||
| 41 | HB (1) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 1 | Chemie (SF4) | |||
| 42 | AC, BC, CC, IC, KB... (I, J, L, W, 4...) | ZINC ION | non-polymer | 65.4 | 17 | Chemie (ZN) PubChem (32051) |
Sequence modifications
c, g: 1 - 130 (UniProt: P06897)
| PDB | External Database | Details |
|---|---|---|
| Arg 100 | Gly 100 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 40 |
| Total formula weight | 1579273.6 | |
| Non-Polymers* | Number of molecules | 49 |
| Total formula weight | 4789.7 | |
| All* | Total formula weight | 1584063.3 |
