29TN
KAT8 MUTANT (KAT6A SURROGATE, MYST-CRYST) IN COMPLEX WITH KAT6A INHIBITOR COMPOUND 38
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Histone acetyltransferase KAT8 | polymer | 278 | 32544.5 | 1 | UniProt (Q9H7Z6) | Homo sapiens (human) | Lysine acetyltransferase 8,MOZ,YBF2/SAS3,SAS2 and TIP60 protein 1,MYST-1,Males-absent on the first protein homolog,hMOF,Protein acetyltransferase KAT8,Protein propionyltransferase KAT8 |
| 2 | B (A) | 6-(dimethylamino)-~{N}-(2-ethoxy-5-propan-2-yl-phenyl)sulfonyl-1-benzofuran-2-carboxamide | non-polymer | 430.5 | 1 | Chemie (A1J4N) | |||
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) PubChem (32051) | |||
| 4 | D (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 5 | E, G (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) PubChem (753) | |||
| 6 | F (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) PubChem (8117) | |||
| 7 | H, I, J, K (A) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) PubChem (312) | |||
| 8 | L (A) | water | water | 18.0 | 210 | Chemie (HOH) |
Sequence modifications
A: 504 - 779 (UniProt: Q9H7Z6)
| PDB | External Database | Details |
|---|---|---|
| Gly 502 | - | expression tag |
| Ser 503 | - | expression tag |
| His 579 | Tyr 249 | engineered mutation |
| Ser 645 | Ala 315 | engineered mutation |
| Met 648 | Leu 318 | engineered mutation |
| Ile 649 | Thr 319 | engineered mutation |
| Arg 660 | Lys 330 | engineered mutation |
| Ser 697 | Trp 367 | engineered mutation |
| Asn 702 | Ile 372 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32544.5 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 952.4 | |
| All* | Total formula weight | 33496.9 |
