29SJ

Three viral endonucleases bound to the same inhibitor (9-hydroxy-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione derivative). (1a) Influenza virus A/pH1N1 PA subunit endonuclease with magnesium ions.

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Polymerase acidic protein	polymer	193	22525.7	1	UniProt (C3W5S0)	Influenza A virus	RNA-directed RNA polymerase subunit P2
2	B (B)	Polymerase acidic protein	polymer	193	22601.8	1	UniProt (C3W5S0)	Influenza A virus	RNA-directed RNA polymerase subunit P2
3	C, D, G, H (A, B)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG) PubChem (888)
4	E, F, I, J (A, B)	9-oxidanyl-6-[(1-phenylcyclohexyl)methyl]-2-propan-2-yl-3,4-dihydropyrazino[1,2-c]pyrimidine-1,8-dione	non-polymer		395.5	4	Chemie (A1J4F) PubChem (86725943)
5	K (B)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL) PubChem (753)
6	L, M (A, B)	water	water		18.0	183	Chemie (HOH)

Sequence modifications

A: 1 - 63 (UniProt: C3W5S0)

PDB	External Database	Details
Gly -6	-	expression tag
Met -5	-	expression tag
Gly -4	-	expression tag
Ser -3	-	expression tag
Gly -2	-	expression tag
Met -1	-	expression tag
Ala 0	-	expression tag

A: 65 - 198 (UniProt: C3W5S0)

PDB	External Database	Details
Gly 64	-	linker

B: 1 - 51 (UniProt: C3W5S0)

PDB	External Database	Details
Gly -6	-	expression tag
Met -5	-	expression tag
Gly -4	-	expression tag
Ser -3	-	expression tag
Gly -2	-	expression tag
Met -1	-	expression tag
Ala 0	-	expression tag

B: 65 - 198 (UniProt: C3W5S0)

PDB	External Database	Details
Gly 64	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	45127.6
Non-Polymers*	Number of molecules	9
	Total formula weight	1771.3
All*	Total formula weight	46898.8

*Water molecules are not included.