29RX
Crystal structure of JAK2 JH1 in complex with ADP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Tyrosine-protein kinase JAK2 | polymer | 316 | 37268.3 | 3 | UniProt (O60674) Pfam (PF07714) | Homo sapiens (human) | Janus kinase 2,JAK-2 |
| 2 | D, F, H (A, B, C) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 3 | Chemie (ADP) | |||
| 3 | E, G, I (A, B, C) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) PubChem (888) | |||
| 4 | J (C) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) PubChem (923) | |||
| 5 | K, L, M (A, B, C) | water | water | 18.0 | 517 | Chemie (HOH) |
Sequence modifications
A, B, C: 840 - 1132 (UniProt: O60674)
| PDB | External Database | Details |
|---|---|---|
| Met 817 | - | initiating methionine |
| His 818 | - | expression tag |
| His 819 | - | expression tag |
| His 820 | - | expression tag |
| His 821 | - | expression tag |
| His 822 | - | expression tag |
| His 823 | - | expression tag |
| Ser 824 | - | expression tag |
| Ser 825 | - | expression tag |
| Gly 826 | - | expression tag |
| Val 827 | - | expression tag |
| Asp 828 | - | expression tag |
| Leu 829 | - | expression tag |
| Gly 830 | - | expression tag |
| Thr 831 | - | expression tag |
| Glu 832 | - | expression tag |
| Asn 833 | - | expression tag |
| Leu 834 | - | expression tag |
| Tyr 835 | - | expression tag |
| Phe 836 | - | expression tag |
| Gln 837 | - | expression tag |
| Ser 838 | - | expression tag |
| Met 839 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 111804.9 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1377.5 | |
| All* | Total formula weight | 113182.4 |
