29MO

Crystal structure of human CLK3 in complex with AZ176

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Dual specificity protein kinase CLK3	polymer	360	42318.4	1	UniProt (P49761)	Homo sapiens (human)	CDC-like kinase 3
2	B, C, E (A)	1,2-ETHANEDIOL	non-polymer		62.1	3	Chemie (EDO)
3	D (A)	3^{3}-methoxy-1^{7}-(2-(2-(4-methylpiperazin-1-yl)ethoxy)ethoxy)-4,7,10-trioxa-2-aza-1(4,6)-quinolina-3(1,2)-benzenacyclodecaphane-1^{3}-carbonitrile	non-polymer		563.6	1	Chemie (A1J3A)
4	F, G, H, I, J (A)	IODIDE ION	non-polymer		126.9	5	Chemie (IOD) PubChem (30165)
5	K (A)	water	water		18.0	104	Chemie (HOH)

Sequence modifications

A: 127 - 484 (UniProt: P49761)

PDB	External Database	Details
Ser 125	-	expression tag
Met 126	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	42318.4
Non-Polymers*	Number of molecules	9
	Total formula weight	1384.4
All*	Total formula weight	43702.8

*Water molecules are not included.