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29MM

Crystal structure of SHP2 in complex with I-0436650

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Tyrosine-protein phosphatase non-receptor type 11polymer52660305.02UniProt (Q06124)Homo sapiens (human)Protein-tyrosine phosphatase 1D,PTP-1D,Protein-tyrosine phosphatase 2C,PTP-2C,SH-PTP2,SHP-2,Shp2,SH-PTP3
2C, F
(A, B)
(4S)-1'-[5-(3-chloranyl-2-pyrazol-1-yl-pyridin-4-yl)sulfanylpyrazin-2-yl]spiro[4,6-dihydropyrrolo[1,2-b]pyrazole-5,4'-piperidine]-4-aminenon-polymer480.02Chemie (A1J30)
3D
(A)
SULFATE IONnon-polymer96.11Chemie (SO4)
4E
(A)
FORMIC ACIDnon-polymer46.01Chemie (FMT)
PubChem (284)
5G
(B)
1,2-ETHANEDIOLnon-polymer62.11Chemie (EDO)
6H, I
(A, B)
waterwater18.0476Chemie (HOH)
Sequence modifications
A, B: 1 - 525 (UniProt: Q06124)
PDBExternal DatabaseDetails
Gly 0-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight120610.0
Non-Polymers*Number of molecules5
Total formula weight1164.1
All*Total formula weight121774.1
*Water molecules are not included.

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PDB entries from 2026-08-12

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