29HO

Ternary complex of VCB, Baz2B-BD with compound 8

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (B)	Elongin-B	polymer	104	11852.4	1	UniProt (Q15370)	Homo sapiens (human)	EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2
2	B (C)	Elongin-C	polymer	97	10974.6	1	UniProt (Q15369)	Homo sapiens (human)	EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1
3	C (D)	Bromodomain adjacent to zinc finger domain protein 2B	polymer	117	13618.7	1	UniProt (Q9UIF8)	Homo sapiens (human)	hWALp4
4	D (V)	Isoform 1 of von Hippel-Lindau disease tumor suppressor	polymer	162	18806.3	1	UniProt (P40337)	Homo sapiens (human)	Protein G7,pVHL
5	E (B)	CACODYLATE ION	non-polymer		137.0	1	Chemie (CAC) PubChem (167250)
6	F, G (V)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	2	Chemie (PEG) PubChem (8117)
7	H (V)	(2~{S},4~{R})-~{N}-[[2-[7-[4-[2-[5-(4-cyanophenyl)-4-(1-methylpyrazol-4-yl)imidazol-1-yl]ethyl]pyrazol-1-yl]heptoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide	non-polymer		972.2	1	Chemie (A1J2L)
8	I, J, K, L (B, C, D, V)	water	water		18.0	40	Chemie (HOH)

Sequence modifications

C: 17 - 112 (UniProt: Q15369)

PDB	External Database	Details
Met 16	-	initiating methionine

D: 2055 - 2168 (UniProt: Q9UIF8)

PDB	External Database	Details
Ser 2052	-	expression tag
Met 2053	-	expression tag
Ser 2054	-	expression tag

V: 59 - 213 (UniProt: P40337)

PDB	External Database	Details
Gly 52	-	expression tag
Ser 53	-	expression tag
Met 54	-	expression tag
Glu 55	-	expression tag
Ala 56	-	expression tag
Gly 57	-	expression tag
Arg 58	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	55251.9
Non-Polymers*	Number of molecules	4
	Total formula weight	1321.4
All*	Total formula weight	56573.3

*Water molecules are not included.