29HN

Crystal structure of Zika virus NS2B-NS3 protease determined via sulfur phasing

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Serine protease subunit NS2B	polymer	46	5067.5	1	UniProt (Q32ZE1) Pfam (PF01002)	Zika virus	Flavivirin protease NS2B regulatory subunit,Non-structural protein 2B
2	B (B)	Serine protease NS3	polymer	168	18117.6	1	UniProt (Q32ZE1) Pfam (PF00949)	Zika virus	Flavivirin protease NS3 catalytic subunit,Non-structural protein 3
3	C, D (A, B)	water	water		18.0	119	Chemie (HOH)

Sequence modifications

A: 46 - 89 (UniProt: Q32ZE1)

PDB	External Database	Details
Ser 44	-	expression tag
Met 45	-	expression tag

B: 11 - 177 (UniProt: Q32ZE1)

PDB	External Database	Details
Met 10	-	initiating methionine
Lys 107	Arg 1605	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	23185.1
All*	Total formula weight	23185.1

*Water molecules are not included.