28ZS

Crystal structure of human DHX8 in complex with compound 53 and ADP

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Glutathione S-transferase class-mu 26 kDa isozyme,ATP-dependent RNA helicase DHX8	polymer	881	100933.3	1	UniProt (P08515) UniProt (Q14562)	Homo sapiens (human)	GST 26,Sj26 antigen,SjGST,DEAH box protein 8,RNA helicase HRH1
2	B (A)	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	1	Chemie (ADP)
3	C (A)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG) PubChem (888)
4	D (A)	2-[(1R)-1-phenyl-2-[4-(propan-2-ylamino)phenyl]ethyl]sulfanylpyridine-3-carboxylic acid	non-polymer		392.5	1	Chemie (A1J1K)
5	E, F, G (A)	DIMETHYL SULFOXIDE	non-polymer		78.1	3	Chemie (DMS) PubChem (679)
6	H (A)	water	water		18.0	200	Chemie (HOH)

Sequence modifications

A: 323 - 540 (UniProt: P08515)

PDB	External Database	Details
Met 308	-	initiating methionine
Ser 309	-	expression tag
Ser 310	-	expression tag
His 311	-	expression tag
His 312	-	expression tag
His 313	-	expression tag
His 314	-	expression tag
His 315	-	expression tag
His 316	-	expression tag
His 317	-	expression tag
His 318	-	expression tag
Asp 319	-	expression tag
Thr 320	-	expression tag
Glu 321	-	expression tag
Glu 322	-	expression tag
Ser 541	-	linker
Asp 542	-	linker
Gly 543	-	linker
Ser 544	-	linker
Glu 545	-	linker
Asn 546	-	linker
Leu 547	-	linker
Tyr 548	-	linker
Phe 549	-	linker
Gln 550	-	linker

A: 551 - 1188 (UniProt: Q14562)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	100933.3
Non-Polymers*	Number of molecules	6
	Total formula weight	1078.4
All*	Total formula weight	102011.7

*Water molecules are not included.