28ZR
Crystal structure of human DHX8 in complex with compound 51 and ADP
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | ATP-dependent RNA helicase DHX8 | polymer | 680 | 77782.6 | 4 | UniProt (Q14562) | Homo sapiens (human) | DEAH box protein 8,RNA helicase HRH1 |
| 2 | BB, E, LA, W (D, A, C, B) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 4 | Chemie (ADP) | |||
| 3 | CB, F, MA, X (D, A, C, B) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) PubChem (888) | |||
| 4 | AA, BA, DB, FA, G... (B, D, A, C) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 16 | Chemie (DMS) PubChem (679) | |||
| 5 | AB, CA, EA, EB, FB... (D, B, A, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 35 | Chemie (EDO) | |||
| 6 | DA, KB, R, UA (B, D, A, C) | 2-[(2S)-1-[4-(propan-2-ylamino)phenyl]propan-2-yl]sulfanylpyridine-3-carboxylic acid | non-polymer | 330.4 | 4 | Chemie (A1J1J) | |||
| 7 | PB, QB, RB, SB (A, B, C, D) | water | water | 18.0 | 812 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 548 - 1220 (UniProt: Q14562)
| PDB | External Database | Details |
|---|---|---|
| Met 547 | - | initiating methionine |
| His 1221 | - | expression tag |
| His 1222 | - | expression tag |
| His 1223 | - | expression tag |
| His 1224 | - | expression tag |
| His 1225 | - | expression tag |
| His 1226 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 311130.6 | |
| Non-Polymers* | Number of molecules | 63 |
| Total formula weight | 6550.3 | |
| All* | Total formula weight | 317680.9 |
