28ZQ

Crystal structure of human DHX8 in complex with compound 43 and ADP

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	ATP-dependent RNA helicase DHX8	polymer	680	77782.6	4	UniProt (Q14562)	Homo sapiens (human)	DEAH box protein 8,RNA helicase HRH1
2	DB, E, PA, Z (D, A, C, B)	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	4	Chemie (ADP)
3	AA, EB, F, QA (B, D, A, C)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG) PubChem (888)
4	DA, G, GA, H, HB... (B, A, D, C)	DIMETHYL SULFOXIDE	non-polymer		78.1	15	Chemie (DMS) PubChem (679)
5	AB, BA, BB, CA, CB... (C, B, D, A)	1,2-ETHANEDIOL	non-polymer		62.1	38	Chemie (EDO)
6	FA, KB, O, YA (B, D, A, C)	2-[(2S)-1-phenylpropan-2-yl]sulfanylpyridine-3-carboxylic acid	non-polymer		273.4	4	Chemie (A1J1I)
7	RB, SB, TB, UB (A, B, C, D)	water	water		18.0	948	Chemie (HOH)

Sequence modifications

A, B, C, D: 548 - 1220 (UniProt: Q14562)

PDB	External Database	Details
Met 547	-	initiating methionine
His 1221	-	expression tag
His 1222	-	expression tag
His 1223	-	expression tag
His 1224	-	expression tag
His 1225	-	expression tag
His 1226	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	311130.6
Non-Polymers*	Number of molecules	65
	Total formula weight	6430.0
All*	Total formula weight	317560.6

*Water molecules are not included.