28ZP
Crystal structure of human DHX8 in complex with compound 34 and ADP
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | ATP-dependent RNA helicase DHX8 | polymer | 680 | 77782.6 | 4 | UniProt (Q14562) | Homo sapiens (human) | DEAH box protein 8,RNA helicase HRH1 |
| 2 | AB, E, OA, Z (D, A, C, B) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 4 | Chemie (ADP) | |||
| 3 | AA, BB, F, PA (B, D, A, C) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) PubChem (888) | |||
| 4 | CA, CB, FA, FB, G... (B, D, A, C) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 15 | Chemie (DMS) PubChem (679) | |||
| 5 | BA, DA, DB, EA, EB... (B, D, A, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 37 | Chemie (EDO) | |||
| 6 | GA, KB, O, XA (B, D, A, C) | 2-[2-[4-(propan-2-ylamino)phenyl]ethylsulfanyl]pyridine-3-carboxylic acid | non-polymer | 316.4 | 4 | Chemie (A1J1H) | |||
| 7 | QB, RB, SB, TB (A, B, C, D) | water | water | 18.0 | 712 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 548 - 1220 (UniProt: Q14562)
| PDB | External Database | Details |
|---|---|---|
| Met 547 | - | initiating methionine |
| His 1221 | - | expression tag |
| His 1222 | - | expression tag |
| His 1223 | - | expression tag |
| His 1224 | - | expression tag |
| His 1225 | - | expression tag |
| His 1226 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 311130.6 | |
| Non-Polymers* | Number of molecules | 64 |
| Total formula weight | 6540.2 | |
| All* | Total formula weight | 317670.8 |
