28ZO

Crystal structure of human DHX8 in complex with compound 24 and ADP

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	ATP-dependent RNA helicase DHX8	polymer	680	77782.6	4	UniProt (Q14562)	Homo sapiens (human)	DEAH box protein 8,RNA helicase HRH1
2	E, FA, OA, W (A, C, D, B)	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	4	Chemie (ADP)
3	F, GA, PA, X (A, C, D, B)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG) PubChem (888)
4	CA, G, H, IA, LA... (B, A, C, D)	DIMETHYL SULFOXIDE	non-polymer		78.1	14	Chemie (DMS) PubChem (679)
5	AA, DA, EA, HA, I... (B, C, A, D)	1,2-ETHANEDIOL	non-polymer		62.1	21	Chemie (EDO)
6	BA, KA, P, VA (B, C, A, D)	2-(2-phenylethylsulfanyl)pyridine-3-carboxylic acid	non-polymer		259.3	4	Chemie (A1J1G)
7	AB, BB, CB, ZA (B, C, D, A)	water	water		18.0	288	Chemie (HOH)

Sequence modifications

A, B, C, D: 548 - 1220 (UniProt: Q14562)

PDB	External Database	Details
Met 547	-	initiating methionine
His 1221	-	expression tag
His 1222	-	expression tag
His 1223	-	expression tag
His 1224	-	expression tag
His 1225	-	expression tag
His 1226	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	311130.6
Non-Polymers*	Number of molecules	47
	Total formula weight	5240.6
All*	Total formula weight	316371.2

*Water molecules are not included.