28ZK

Crystal structure of human DHX8 in complex with compound 5 and ADP

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	ATP-dependent RNA helicase DHX8	polymer	680	77782.6	4	UniProt (Q14562)	Homo sapiens (human)	DEAH box protein 8,RNA helicase HRH1
2	AB, E, OA, Z (D, A, C, B)	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	4	Chemie (ADP)
3	AA, BB, F, PA (B, D, A, C)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG) PubChem (888)
4	CB, EA, FA, G, GB... (D, B, A, C)	DIMETHYL SULFOXIDE	non-polymer		78.1	19	Chemie (DMS) PubChem (679)
5	BA, CA, DA, DB, EB... (B, D, A, C)	1,2-ETHANEDIOL	non-polymer		62.1	30	Chemie (EDO)
6	KA, LB, T, YA (B, D, A, C)	2-(4-chloranylphenoxy)pyridine-3-carboxylic acid	non-polymer		249.7	4	Chemie (A1J1D)
7	NB, OB, PB, QB (A, B, C, D)	water	water		18.0	623	Chemie (HOH)

Sequence modifications

A, B, C, D: 548 - 1220 (UniProt: Q14562)

PDB	External Database	Details
Met 547	-	initiating methionine
His 1221	-	expression tag
His 1222	-	expression tag
His 1223	-	expression tag
His 1224	-	expression tag
His 1225	-	expression tag
His 1226	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	311130.6
Non-Polymers*	Number of molecules	61
	Total formula weight	6151.2
All*	Total formula weight	317281.8

*Water molecules are not included.