28ZJ
Crystal structure of human DHX8 in complex with compound 4 and ADP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | ATP-dependent RNA helicase DHX8 | polymer | 680 | 77782.6 | 4 | UniProt (Q14562) | Homo sapiens (human) | DEAH box protein 8,RNA helicase HRH1 |
| 2 | AA, E, YB, ZA (B, A, D, C) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 4 | Chemie (ADP) | |||
| 3 | AB, BA, F, ZB (C, B, A, D) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) PubChem (888) | |||
| 4 | AC, BB, CA, CC, DC... (D, C, B, A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 45 | Chemie (DMS) PubChem (679) | |||
| 5 | BC, DA, DB, H (D, B, C, A) | IBUPROFEN | non-polymer | 206.3 | 4 | Chemie (IBP) PubChem (39912) | |||
| 6 | NA, OA, PA, PC, Q... (B, D, A, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 35 | Chemie (EDO) | |||
| 7 | CB (C) | (2R)-2-[4-(2-methylpropyl)phenyl]propanoic acid | non-polymer | 206.3 | 1 | Chemie (IZP) PubChem (114864) | |||
| 8 | EB (C) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) PubChem (312) | |||
| 9 | UC, VC, WC, XC (A, B, C, D) | water | water | 18.0 | 595 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 548 - 1220 (UniProt: Q14562)
| PDB | External Database | Details |
|---|---|---|
| Met 547 | - | initiating methionine |
| His 1221 | - | expression tag |
| His 1222 | - | expression tag |
| His 1223 | - | expression tag |
| His 1224 | - | expression tag |
| His 1225 | - | expression tag |
| His 1226 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 311130.6 | |
| Non-Polymers* | Number of molecules | 94 |
| Total formula weight | 8561.2 | |
| All* | Total formula weight | 319691.8 |
