28WF

SARS-CoV-2 nsp16-nsp10 in complex with SAM derivative ligand AD1

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	2'-O-methyltransferase nsp16	polymer	302	33701.6	1	UniProt (P0DTD1)	Severe acute respiratory syndrome coronavirus 2	Non-structural protein 16,nsp16
2	B (B)	Non-structural protein 10	polymer	142	15106.3	1	UniProt (P0DTC1)	Severe acute respiratory syndrome coronavirus 2	nsp10,Growth factor-like peptide,GFL
3	C (A)	2-(N-MORPHOLINO)-ETHANESULFONIC ACID	non-polymer		195.2	1	Chemie (MES)
4	D (A)	[(2~{S},6~{R})-6-(6-aminopurin-9-yl)morpholin-2-yl]methanol	non-polymer		250.3	1	Chemie (A1J0V)
5	E, F (B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
6	G, H (A, B)	water	water		18.0	310	Chemie (HOH)

Sequence modifications

A: 1 - 298 (UniProt: P0DTD1)

PDB	External Database	Details
Gly -3	-	expression tag
Ser -2	-	expression tag
Met -1	-	expression tag
Ala 0	-	expression tag

B: 1 - 139 (UniProt: P0DTC1)

PDB	External Database	Details
Gly -2	-	expression tag
Ser -1	-	expression tag
Met 0	-	expression tag
Arg 113	Lys 4366	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	48807.9
Non-Polymers*	Number of molecules	4
	Total formula weight	576.3
All*	Total formula weight	49384.2

*Water molecules are not included.