28VK
Cryo-EM structure of mosquito OPN3 in complex with the Gi heterotrimer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40415.0 | 1 | UniProt (P63096) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 340 | 37416.9 | 1 | UniProt (P62873) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 70 | 7729.9 | 1 | UniProt (P59768) | Homo sapiens (human) | G gamma-I |
| 4 | D (R) | G-protein coupled receptors family 1 profile domain-containing protein | polymer | 330 | 36938.1 | 1 | UniProt (A0A182R9Y7) | Anopheles stephensi (Asian malaria mosquito) | |
| 5 | E (R) | RETINAL | non-polymer | 284.4 | 1 | Chemie (RET) PubChem (638015) PubChem (5381765) | |||
| 6 | F, G, H, I, J... (R) | CHOLESTEROL | non-polymer | 386.7 | 6 | Chemie (CLR) PubChem (5997) |
Sequence modifications
R: 1 - 330 (UniProt: A0A182R9Y7)
| PDB | External Database | Details |
|---|---|---|
| Tyr 2 | Asn 2 | conflict |
| Asp 3 | Glu 3 | conflict |
| Val 12 | Ala 12 | conflict |
| Ala 13 | Val 13 | conflict |
| Ile 29 | Val 29 | conflict |
| Phe 33 | Cys 33 | conflict |
| Gln 167 | Glu 167 | conflict |
| Tyr 214 | Asn 214 | conflict |
| Arg 217 | Lys 217 | conflict |
| Val 308 | Met 308 | conflict |
| Pro 309 | Gln 309 | conflict |
| Thr 310 | Met 310 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 122500.0 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2604.4 | |
| All* | Total formula weight | 125104.3 |
