26RW
Crystal structure of the C65A/M94W/M145W/C167A mutant of Human lipocalin-type Prostaglandin D Synthase in complex with 10-O-(3-fluoropropyl)-substituted SN-38
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Prostaglandin-H2 D-isomerase | polymer | 170 | 18907.0 | 1 | UniProt (P41222) Pfam (PF00061) | Homo sapiens (human) | Beta-trace protein,Cerebrin-28,Glutathione-independent PGD synthase,Lipocalin-type prostaglandin-D synthase,L-PGDS,Prostaglandin-D2 synthase,PGD2 synthase,PGDS,PGDS2 |
| 2 | B, C (A) | (4S)-4,11-diethyl-9-(3-fluoropropoxy)-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione | non-polymer | 452.5 | 2 | Chemie (A1MG3) | |||
| 3 | D (A) | water | water | 18.0 | 106 | Chemie (HOH) |
Sequence modifications
A: 21 - 190 (UniProt: P41222)
| PDB | External Database | Details |
|---|---|---|
| Gly 21 | Gln 21 | engineered mutation |
| Ser 22 | Ala 22 | engineered mutation |
| Ala 65 | Cys 65 | engineered mutation |
| Trp 94 | Met 94 | engineered mutation |
| Trp 145 | Met 145 | engineered mutation |
| Ala 167 | Cys 167 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 18907.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 905.0 | |
| All* | Total formula weight | 19812.0 |
