26PJ
X-ray crystal structure of R28D mutant of the human NBS1 FHA-BRCT1-BRCT2 domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Nibrin | polymer | 334 | 37192.5 | 2 | UniProt (O60934) Pfam (PF00498) Pfam (PF00533) Pfam (PF16508) | Homo sapiens (human) | Cell cycle regulatory protein p95,Nijmegen breakage syndrome protein 1,hNbs1 |
| 2 | C, D, F (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 3 | Chemie (PO4) PubChem (1061) | |||
| 3 | E (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 56 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 326 (UniProt: O60934)
| PDB | External Database | Details |
|---|---|---|
| Asp 28 | Arg 28 | engineered mutation |
| Leu 327 | - | expression tag |
| Glu 328 | - | expression tag |
| His 329 | - | expression tag |
| His 330 | - | expression tag |
| His 331 | - | expression tag |
| His 332 | - | expression tag |
| His 333 | - | expression tag |
| His 334 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 74385.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 347.0 | |
| All* | Total formula weight | 74732.0 |
