25XM

Cryo-EM structure of the Crimean-Congo hemorrhagic fever virus L protein (5'-cRNA-bound form)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	RNA-directed RNA polymerase L	polymer	3989	453202.3	1	UniProt (A0A068JD44)	Orthonairovirus haemorrhagiae	Large structural protein,Replicase,Transcriptase
2	B (B)	RNA (5'-R(*UP*CP*UP*CP*AP*AP*AP*GP*AP*UP*AP*UP*CP*A)-3')	polymer	14	4415.7	1		synthetic construct
3	C, D (A)	ZINC ION	non-polymer		65.4	2	Chemie (ZN) PubChem (32051)

Sequence modifications

A: 2 - 3945 (UniProt: A0A068JD44)

PDB	External Database	Details
Met -43	-	initiating methionine
Trp -42	-	expression tag
Ser -41	-	expression tag
His -40	-	expression tag
Pro -39	-	expression tag
Gln -38	-	expression tag
Phe -37	-	expression tag
Glu -36	-	expression tag
Lys -35	-	expression tag
Gly -34	-	expression tag
Gly -33	-	expression tag
Gly -32	-	expression tag
Ser -31	-	expression tag
Gly -30	-	expression tag
Gly -29	-	expression tag
Gly -28	-	expression tag
Ser -27	-	expression tag
Gly -26	-	expression tag
Gly -25	-	expression tag
Gly -24	-	expression tag
Ser -23	-	expression tag
Trp -22	-	expression tag
Ser -21	-	expression tag
His -20	-	expression tag
Pro -19	-	expression tag
Gln -18	-	expression tag
Phe -17	-	expression tag
Glu -16	-	expression tag
Lys -15	-	expression tag
Gly -14	-	expression tag
Ser -13	-	expression tag
Ser -12	-	expression tag
Ser -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
Ser 0	-	expression tag
Ser 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	457618.0
Non-Polymers*	Number of molecules	2
	Total formula weight	130.8
All*	Total formula weight	457748.8

*Water molecules are not included.