24VC
Structure of lumen-open ABCD4-LMBD1 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Lysosomal cobalamin transporter ABCD4 | polymer | 606 | 68693.1 | 2 | UniProt (O14678) | Homo sapiens (human) | ATP-binding cassette sub-family D member 4,PMP70-related protein,P70R,Peroxisomal membrane protein 1-like,PXMP1-L,Peroxisomal membrane protein 69,PMP69 |
| 2 | C (C) | Lysosomal cobalamin transport escort protein LMBD1 | polymer | 540 | 61431.4 | 1 | UniProt (Q9NUN5) | Homo sapiens (human) | LMBD1,HDAg-L-interacting protein NESI,LMBR1 domain-containing protein 1,Nuclear export signal-interacting protein |
| 3 | D, F (A, B) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 4 | E, H (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 5 | G (B) | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) PubChem (5997) |
Sequence modifications
A, B: 1 - 606 (UniProt: O14678)
C: 1 - 540 (UniProt: Q9NUN5)
| PDB | External Database | Details |
|---|---|---|
| Thr 304 | Ala 304 | variant |
| Lys 368 | Glu 368 | variant |
| Gln 549 | Glu 549 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Val 395 | Ile 395 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 198817.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1449.6 | |
| All* | Total formula weight | 200267.3 |
