24SS
Human KRAS WT (GDP-bound) in complex with macrocyclic peptide inhibitor AUBE00
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Isoform 2B of GTPase KRas | polymer | 179 | 20092.5 | 3 | UniProt (P01116) Pfam (PF00071) | Homo sapiens (human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | D, E, F (I, J, K) | AUBE00 | polymer | 12 | 1599.8 | 3 | synthetic construct | ||
| 3 | G, KA, V (A, C, B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 3 | Chemie (GDP) | |||
| 4 | AA, BA, CA, DA, EA... (B, A, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 32 | Chemie (EDO) | |||
| 5 | HA, Q, SA (B, A, C) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) PubChem (888) | |||
| 6 | T, TA (A, C) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 7 | UA (C) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) PubChem (679) | |||
| 8 | AB, VA, WA, XA, YA... (K, A, B, C, I...) | water | water | 18.0 | 556 | Chemie (HOH) |
Sequence modifications
A, B, C: 2 - 174 (UniProt: P01116)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Ser -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 65077.2 | |
| Non-Polymers* | Number of molecules | 41 |
| Total formula weight | 3659.0 | |
| All* | Total formula weight | 68736.1 |
