24SR
Human NRAS WT (GDP-bound) in complex with macrocyclic peptide inhibitor AP6296
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | GTPase NRas | polymer | 177 | 19872.4 | 3 | UniProt (P01111) Pfam (PF00071) | Homo sapiens (human) | Transforming protein N-Ras |
| 2 | D, E, F (I, J, K) | AP6296 | polymer | 12 | 1484.2 | 3 | synthetic construct | ||
| 3 | G, M, U (A, B, C) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 3 | Chemie (GDP) | |||
| 4 | BA, CA, H, I, J... (K, A, B, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 16 | Chemie (EDO) | |||
| 5 | AA, L, S (C, A, B) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) PubChem (888) | |||
| 6 | T (B) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) PubChem (1061) | |||
| 7 | DA, EA, FA, GA, HA... (A, B, C, I, J...) | water | water | 18.0 | 415 | Chemie (HOH) |
Sequence modifications
A, B, C: 2 - 172 (UniProt: P01111)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Ser -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 64069.8 | |
| Non-Polymers* | Number of molecules | 23 |
| Total formula weight | 2490.6 | |
| All* | Total formula weight | 66560.4 |
