24KJ
Crystal structure of second bromodomain (BD2) of human BRD2 in complex with 2PE and P6G
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Bromodomain-containing protein 2 | polymer | 111 | 12968.8 | 1 | UniProt (P25440) | Homo sapiens (human) | O27.1.1 |
| 2 | B (A) | NONAETHYLENE GLYCOL | non-polymer | 414.5 | 1 | Chemie (2PE) | |||
| 3 | C (A) | HEXAETHYLENE GLYCOL | non-polymer | 282.3 | 1 | Chemie (P6G) | |||
| 4 | D (A) | water | water | 18.0 | 129 | Chemie (HOH) |
Sequence modifications
A: 348 - 455 (UniProt: P25440)
| PDB | External Database | Details |
|---|---|---|
| Ala 345 | - | expression tag |
| Asn 346 | - | expression tag |
| Pro 347 | - | expression tag |
| Ser 358 | Lys 358 | engineered mutation |
| Ser 363 | Lys 363 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 12968.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 696.8 | |
| All* | Total formula weight | 13665.6 |
