24IC

Crystal structure of human RIPK1 kinase domain in complex with compound HR97

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Receptor-interacting serine/threonine-protein kinase 1	polymer	294	33468.7	2	UniProt (Q13546)	Homo sapiens (human)	Cell death protein RIP,Receptor-interacting protein 1,RIP-1
2	C, D (A, B)	(3~{S})-~{N}-(cyclopropylmethyl)-5-methyl-4-oxidanylidene-3-[[5-(phenylmethyl)-4~{H}-1,2,4-triazol-3-yl]carbonylamino]-2,3-dihydro-1,5-benzoxazepine-7-carboxamide	non-polymer		474.5	2	Chemie (A1E6R)
3	E, F (A, B)	water	water		18.0	7	Chemie (HOH)

Sequence modifications

A, B: 1 - 294 (UniProt: Q13546)

PDB	External Database	Details
Ala 34	Cys 34	engineered mutation
Ala 127	Cys 127	engineered mutation
Ala 233	Cys 233	engineered mutation
Ala 240	Cys 240	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	66937.5
Non-Polymers*	Number of molecules	2
	Total formula weight	949.0
All*	Total formula weight	67886.5

*Water molecules are not included.