23SR

Cryo-EM structure of CDK2 in complex with CRBN/DDB1 and B11

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (B)	Protein cereblon	polymer	477	53782.0	1	UniProt (Q96SW2) Pfam (PF02190) Pfam (PF03226)	Homo sapiens (human)
2	B (C)	Oplophorus-luciferin 2-monooxygenase catalytic subunit,Cyclin-dependent kinase 2,GFP-like fluorescent chromoprotein	polymer	729	82203.5	1	UniProt (P24941) Pfam (PF00069)	synthetic construct	Cell division protein kinase 2,p33 protein kinase
3	C (A)	DNA damage-binding protein 1	polymer	836	93347.1	1		Homo sapiens
4	D (B)	spiro[3.3]heptan-2-ylmethyl ~{N}-[[3-[(3~{R})-2,6-bis(oxidanylidene)piperidin-3-yl]-8-chloranyl-6-fluoranyl-4-oxidanylidene-quinazolin-7-yl]methyl]carbamate	non-polymer		490.9	1	Chemie (A1E59)

Sequence modifications

B: 40 - 442 (UniProt: Q96SW2)

PDB	External Database	Details
Met 2	-	initiating methionine
Ser 3	-	expression tag
Tyr 4	-	expression tag
Tyr 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
His 11	-	expression tag
Gly 12	-	expression tag
Ser 13	-	expression tag
Asp 14	-	expression tag
Tyr 15	-	expression tag
Lys 16	-	expression tag
Asp 17	-	expression tag
Asp 18	-	expression tag
Asp 19	-	expression tag
Asp 20	-	expression tag
Val 21	-	expression tag
Asp 22	-	expression tag
Tyr 23	-	expression tag
Asp 24	-	expression tag
Ile 25	-	expression tag
Pro 26	-	expression tag
Thr 27	-	expression tag
Thr 28	-	expression tag
Glu 29	-	expression tag
Asn 30	-	expression tag
Leu 31	-	expression tag
Tyr 32	-	expression tag
Phe 33	-	expression tag
Gln 34	-	expression tag
Gly 35	-	expression tag
Ala 36	-	expression tag
Met 37	-	expression tag
Gly 38	-	expression tag
Ser 39	-	expression tag
Gly 443	-	expression tag
Ser 444	-	expression tag
Ser 445	-	expression tag
Gly 446	-	expression tag
Gly 447	-	expression tag
Gly 448	-	expression tag
Gly 449	-	expression tag
Ser 450	-	expression tag
Gly 451	-	expression tag
Gly 452	-	expression tag
Gly 453	-	expression tag
Ser 454	-	expression tag
Ser 455	-	expression tag
Gly 456	-	expression tag
Gly 457	-	expression tag
Gly 458	-	expression tag
Gly 459	-	expression tag
Ser 460	-	expression tag
Gly 461	-	expression tag
Gly 462	-	expression tag
Gly 463	-	expression tag
Gly 464	-	expression tag
Ser 465	-	expression tag
Ser 466	-	expression tag
Gly 467	-	expression tag
Val 468	-	expression tag
Ser 469	-	expression tag
Gly 470	-	expression tag
Trp 471	-	expression tag
Arg 472	-	expression tag
Leu 473	-	expression tag
Phe 474	-	expression tag
Lys 475	-	expression tag
Lys 476	-	expression tag
Ile 477	-	expression tag
Ser 478	-	expression tag

C: -201 - 0 (PDB: 23SR)
C: 1 - 298 (UniProt: P24941)
C: 299 - 527 (PDB: 23SR)

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	229332.6
Non-Polymers*	Number of molecules	1
	Total formula weight	490.9
All*	Total formula weight	229823.5

*Water molecules are not included.