23SO
Cryo-EM structure of the cebranopadol-mu opioid receptor-Gi complex
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 345 | 37915.5 | 1 | UniProt (P54311) | Rattus norvegicus (Norway rat) | Transducin beta chain 1 |
| 2 | B (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 68 | 7563.8 | 1 | UniProt (P63212) | Bos taurus (domestic cattle) | G gamma-I |
| 3 | C, F (F, A) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40445.1 | 2 | UniProt (P63096) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 4 | D, E (M, R) | Mu-type opioid receptor | polymer | 400 | 44817.2 | 2 | UniProt (P35372) | Homo sapiens (human) | M-OR-1,MOR-1,Mu opiate receptor,Mu opioid receptor,MOP,hMOP |
| 5 | G (E) | scFv16 | polymer | 247 | 26277.3 | 1 | synthetic construct | ||
| 6 | H, I, J, K, L... (M, R) | CHOLESTEROL | non-polymer | 386.7 | 10 | Chemie (CLR) PubChem (5997) | |||
| 7 | M, S (M, R) | Cebranopadol | non-polymer | 378.5 | 2 | Chemie (A1E5L) |
Sequence modifications
B: 2 - 340 (UniProt: P54311)
F, A: 1 - 354 (UniProt: P63096)
| PDB | External Database | Details |
|---|---|---|
| Met -4 | - | initiating methionine |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Gln 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 203 | Gly 203 | engineered mutation |
| Ser 326 | Ala 326 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 242281.1 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 4623.5 | |
| All* | Total formula weight | 246904.6 |
