23OI
Cryo-EM structure of the cebranopadol-NOP receptor-Gi complex
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 345 | 37915.5 | 1 | UniProt (P54311) | Rattus norvegicus (Norway rat) | Transducin beta chain 1 |
| 2 | B (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 68 | 7563.8 | 1 | UniProt (P63212) | Bos taurus (domestic cattle) | G gamma-I |
| 3 | C (R) | Nociceptin receptor | polymer | 370 | 40729.1 | 1 | UniProt (P41146) | Homo sapiens (human) | Kappa-type 3 opioid receptor,KOR-3,Orphanin FQ receptor |
| 4 | D (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40445.1 | 1 | UniProt (P63096) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 5 | E (R) | Cebranopadol | non-polymer | 378.5 | 1 | Chemie (A1E5L) |
Sequence modifications
B: 2 - 340 (UniProt: P54311)
A: 1 - 354 (UniProt: P63096)
| PDB | External Database | Details |
|---|---|---|
| Met -4 | - | initiating methionine |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Gln 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 203 | Gly 203 | engineered mutation |
| Ser 326 | Ala 326 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 126653.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 378.5 | |
| All* | Total formula weight | 127031.9 |
