23LZ
Crystal structure of SARS-CoV-2 main protease G143S mutant in complex with leritrelvir
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | 3C-like proteinase nsp5 | polymer | 306 | 33855.6 | 4 | UniProt (P0DTD1) Pfam (PF05409) | Severe acute respiratory syndrome coronavirus 2 | 3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase |
| 2 | E, G, H, I, J... (A, B, C, D) | GLYCEROL | non-polymer | 92.1 | 14 | Chemie (GOL) PubChem (753) | |||
| 3 | F, L, S, V (A, B, C, D) | Leritrelvir bound form | non-polymer | 641.7 | 4 | Chemie (7ON) | |||
| 4 | W, X, Y, Z (A, B, C, D) | water | water | 18.0 | 311 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 306 (UniProt: P0DTD1)
| PDB | External Database | Details |
|---|---|---|
| Ser 143 | Gly 3406 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 135422.3 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 3856.2 | |
| All* | Total formula weight | 139278.5 |
