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23JV

Crystal structure of human cytosolic NADP(+)-dependent malic enzyme in complex with small molecules

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, D
(A, C, B, D)
NADP-dependent malic enzymepolymer57264223.44UniProt (P48163)
Pfam (PF00390)
Pfam (PF03949)
Homo sapiens (human)NADP-ME,Malic enzyme 1
2E, G, J, L
(A, C, B, D)
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATEnon-polymer743.44Chemie (NAP)
3F, I, K, N
(A, C, B, D)
MANGANESE (II) IONnon-polymer54.94Chemie (MN)
PubChem (27854)
4H, M
(C, D)
(2S)-2-HYDROXYPROPANOIC ACIDnon-polymer90.12Chemie (2OP)
PubChem (107689)
5O, P, Q, R
(A, C, B, D)
waterwater18.01268Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight256893.5
Non-Polymers*Number of molecules10
Total formula weight3373.5
All*Total formula weight260267.1
*Water molecules are not included.

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PDB entries from 2026-09-30

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