23FD
Cryo-EM structure of human ATR-ATRIP complex with ATPgammaS, Chk1 and TopBp1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Serine/threonine-protein kinase ATR | polymer | 2644 | 301756.8 | 2 | UniProt (Q13535) | Homo sapiens (human) | Ataxia telangiectasia and Rad3-related protein,FRAP-related protein 1 |
| 2 | C, D (C, D) | ATR-interacting protein | polymer | 791 | 85940.7 | 2 | UniProt (Q8WXE1) | Homo sapiens (human) | ATM and Rad3-related-interacting protein |
| 3 | E, F (E, F) | Serine/threonine-protein kinase Chk1 | polymer | 14 | 1550.7 | 2 | UniProt (O14757) | Homo sapiens | CHK1 checkpoint homolog,Cell cycle checkpoint kinase,Checkpoint kinase-1 |
| 4 | G, H (G, H) | DNA topoisomerase 2-binding protein 1 | polymer | 545 | 61099.6 | 2 | UniProt (Q92547) | Homo sapiens (human) | DNA topoisomerase II-beta-binding protein 1,TopBP1,DNA topoisomerase II-binding protein 1 |
| 5 | I, L (A, B) | PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | non-polymer | 523.2 | 2 | Chemie (AGS) | |||
| 6 | J, K, M, N (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) PubChem (888) | |||
| 7 | O, P (C, D) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) PubChem (32051) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 900695.5 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1274.5 | |
| All* | Total formula weight | 901970.1 |
