22UK
Crystal structure of human cGAS in complex with NF023
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Cyclic GMP-AMP synthase | polymer | 371 | 43405.9 | 2 | UniProt (Q8N884) Pfam (PF03281) Pfam (PF20266) | Homo sapiens (human) | cGAMP synthase,cGAS,h-cGAS,2'3'-cGAMP synthase,Mab-21 domain-containing protein 1 |
| 2 | C, F, G (A, B) | 8-({3-[({3-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl}carbamoyl)amino]benzoyl}amino)naphthalene-1,3,5-trisulfonic acid | non-polymer | 1031.0 | 3 | Chemie (0BU) PubChem (4466) | |||
| 3 | D (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) PubChem (8117) | |||
| 4 | E, H (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) PubChem (32051) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 78 | Chemie (HOH) |
Sequence modifications
A, B: 157 - 522 (UniProt: Q8N884)
| PDB | External Database | Details |
|---|---|---|
| Ser 152 | - | expression tag |
| Glu 153 | - | expression tag |
| Phe 154 | - | expression tag |
| Glu 155 | - | expression tag |
| Leu 156 | - | expression tag |
| His 261 | Pro 261 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 86811.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 3329.9 | |
| All* | Total formula weight | 90141.8 |
