22PL

Structure of the IL-31/IL-31RA/OSMRB complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Interleukin-31	polymer	141	15856.1	1	UniProt (Q6EBC2)	Homo sapiens (human)	IL-31
2	B (B)	Interleukin-31 receptor subunit alpha	polymer	212	24864.2	1	UniProt (Q8NI17)	Homo sapiens (human)	IL-31 receptor subunit alpha,IL-31R subunit alpha,IL-31R-alpha,IL-31RA,Cytokine receptor-like 3,GLM-R,hGLM-R,Gp130-like monocyte receptor,Gp130-like receptor,ZcytoR17
3	C (C)	Oncostatin-M-specific receptor subunit beta	polymer	311	36236.5	1	UniProt (Q99650)	Homo sapiens (human)	Interleukin-31 receptor subunit beta,IL-31 receptor subunit beta,IL-31R subunit beta,IL-31R-beta,IL-31RB
4	D (D)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
5	E (E)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	1	In PDB GlyTouCan (G15407YE)
6	F, G (B, C)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG) PubChem (24139)

Sequence modifications

B: 20 - 225 (UniProt: Q8NI17)

PDB	External Database	Details
His 226	-	expression tag
His 227	-	expression tag
His 228	-	expression tag
His 229	-	expression tag
His 230	-	expression tag
His 231	-	expression tag

C: 28 - 332 (UniProt: Q99650)

PDB	External Database	Details
His 333	-	expression tag
His 334	-	expression tag
His 335	-	expression tag
His 336	-	expression tag
His 337	-	expression tag
His 338	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	76956.8
Branched	Number of molecules	2
	Total formula weight	1010.9
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	78410.1

*Water molecules are not included.