22JZ

Cryo-EM structure of the mGlu7-beta-arrestin 1 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Isoform 4 of Metabotropic glutamate receptor 7	polymer	909	102004.6	2	UniProt (Q14831)	Homo sapiens (human)	mGluR7
2	C, E (C, E)	beta-arrestin 1	polymer	505	56556.0	2		Homo sapiens
3	D (D)	scFv30	polymer	111	11976.3	1		Mus musculus
4	F, J (A, B)	GLUTAMIC ACID	non-polymer		147.1	2	Chemie (GLU) PubChem (33032)
5	G, H, I, K, L (A, B)	CHOLESTEROL	non-polymer		386.7	5	Chemie (CLR) PubChem (5997)

Sequence modifications

A, B: 35 - 875 (UniProt: Q14831)

PDB	External Database	Details
Asp -4	-	expression tag
Tyr -3	-	expression tag
Lys -2	-	expression tag
Asp -1	-	expression tag
Asp 0	-	expression tag
Asp 1	-	expression tag
Asp 2	-	expression tag
Gly 3	-	expression tag
Ser 4	-	expression tag
Trp 5	-	expression tag
Ser 6	-	expression tag
His 7	-	expression tag
Pro 8	-	expression tag
Gln 9	-	expression tag
Phe 10	-	expression tag
Glu 11	-	expression tag
Lys 12	-	expression tag
Gly 13	-	expression tag
Ser 14	-	expression tag
Gly 15	-	expression tag
Ser 16	-	expression tag
Trp 17	-	expression tag
Ser 18	-	expression tag
His 19	-	expression tag
Pro 20	-	expression tag
Gln 21	-	expression tag
Phe 22	-	expression tag
Glu 23	-	expression tag
Lys 24	-	expression tag
Gly 25	-	expression tag
Ser 26	-	expression tag
Ser 27	-	expression tag
Glu 28	-	expression tag
Asn 29	-	expression tag
Leu 30	-	expression tag
Tyr 31	-	expression tag
Phe 32	-	expression tag
Gln 33	-	expression tag
Ser 34	-	expression tag
Ala 876	-	expression tag
Arg 877	-	expression tag
Gly 878	-	expression tag
Arg 879	-	expression tag
Thr 880	-	expression tag
Pro 881	-	expression tag
Pro 882	-	expression tag
Ser 883	-	expression tag
Leu 884	-	expression tag
Gly 885	-	expression tag
Pro 886	-	expression tag
Gln 887	-	expression tag
Asp 888	-	expression tag
Glu 889	-	expression tag
Ser 890	-	expression tag
Cys 891	-	expression tag
Tpo 892	-	expression tag
Tpo 893	-	expression tag
Ala 894	-	expression tag
Sep 895	-	expression tag
Sep 896	-	expression tag
Sep 897	-	expression tag
Leu 898	-	expression tag
Ala 899	-	expression tag
Lys 900	-	expression tag
Asp 901	-	expression tag
Thr 902	-	expression tag
Ser 903	-	expression tag
Ser 904	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	329097.7
Non-Polymers*	Number of molecules	7
	Total formula weight	2227.5
All*	Total formula weight	331325.2

*Water molecules are not included.