22HP
SARS-CoV-2 BA.3.2.2(RE.2.2) RBD in complex with monoclonal antibodies S2K146 and L4.65
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Spike protein S1 | polymer | 186 | 21462.1 | 1 | UniProt (P0DTC2) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2) | |
| 2 | B (H) | The heavy chain of monoclonal antibody L4.65 | polymer | 127 | 14270.9 | 1 | Homo sapiens | ||
| 3 | C (L) | The light chain of monoclonal antibody L4.65 | polymer | 108 | 11796.0 | 1 | Homo sapiens | ||
| 4 | D (T) | The heavy chain of monoclonal antibody S2K146 | polymer | 120 | 13207.8 | 1 | Homo sapiens | ||
| 5 | E (t) | The light chain of monoclonal antibody S2K146 | polymer | 93 | 9637.5 | 1 | Homo sapiens | ||
| 6 | F, G (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) PubChem (24139) |
Sequence modifications
A: 336 - 521 (UniProt: P0DTC2)
| PDB | External Database | Details |
|---|---|---|
| Tyr 339 | Gly 339 | conflict |
| Pro 348 | Ala 348 | conflict |
| Thr 356 | Lys 356 | conflict |
| Phe 371 | Ser 371 | variant |
| Pro 373 | Ser 373 | variant |
| Phe 375 | Ser 375 | variant |
| Lys 403 | Arg 403 | conflict |
| Asn 405 | Asp 405 | variant |
| Ser 408 | Arg 408 | variant |
| Asn 417 | Lys 417 | variant |
| Ser 435 | Ala 435 | conflict |
| Arg 440 | Asn 440 | conflict |
| Ala 445 | Val 445 | conflict |
| Asp 446 | Gly 446 | conflict |
| Trp 452 | Leu 452 | conflict |
| Lys 460 | Asn 460 | variant |
| Asn 477 | Ser 477 | variant |
| Asn 478 | Thr 478 | conflict |
| Lys 484 | Glu 484 | variant |
| Ser 496 | Gly 496 | variant |
| Arg 498 | Gln 498 | variant |
| Tyr 501 | Asn 501 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 70374.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 442.4 | |
| All* | Total formula weight | 70816.8 |
