22GE
The structure of HER2-r40-trastuzumab-pertuzumab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Receptor tyrosine-protein kinase erbB-2 | polymer | 664 | 73051.8 | 1 | UniProt (P04626) Pfam (PF01030) Pfam (PF00757) Pfam (PF14843) | Homo sapiens (human) | Metastatic lymph node gene 19 protein,MLN 19,Proto-oncogene Neu,Proto-oncogene c-ErbB-2,Tyrosine kinase-type cell surface receptor HER2,p185erbB2 |
| 2 | B (B) | Pertuzumab FAB LIGHT CHAIN | polymer | 236 | 25893.9 | 1 | Homo sapiens (human) | ||
| 3 | C (C) | Pertuzumab FAB HEAVY CHAIN | polymer | 235 | 25220.1 | 1 | Homo sapiens (human) | ||
| 4 | D (D) | Trastuzumab FAB LIGHT CHAIN | polymer | 236 | 25811.8 | 1 | Homo sapiens (human) | ||
| 5 | E (E) | Trastuzumab FAB HEAVY CHAIN | polymer | 236 | 25306.3 | 1 | Homo sapiens (human) | ||
| 6 | F (G) | r40 (rabbit-derived) HEAVY CHAIN | polymer | 237 | 25131.0 | 1 | Oryctolagus cuniculus | ||
| 7 | G (H) | r40 (rabbit-derived) LIGHT CHAIN | polymer | 255 | 26921.7 | 1 | Oryctolagus cuniculus |
Sequence modifications
A: 23 - 652 (UniProt: P04626)
| PDB | External Database | Details |
|---|---|---|
| Gly -11 | - | expression tag |
| Pro -10 | - | expression tag |
| Gly -9 | - | expression tag |
| Gly -8 | - | expression tag |
| Ser -7 | - | expression tag |
| Arg -6 | - | expression tag |
| Gly -5 | - | expression tag |
| Val -4 | - | expression tag |
| Pro -3 | - | expression tag |
| His -2 | - | expression tag |
| Ile -1 | - | expression tag |
| Val 0 | - | expression tag |
| Met 1 | - | expression tag |
| Val 2 | - | expression tag |
| Asp 3 | - | expression tag |
| Ala 4 | - | expression tag |
| Tyr 5 | - | expression tag |
| Lys 6 | - | expression tag |
| Arg 7 | - | expression tag |
| Tyr 8 | - | expression tag |
| Lys 9 | - | expression tag |
| Gly 10 | - | expression tag |
| Gly 11 | - | expression tag |
| Ser 12 | - | expression tag |
| Asp 13 | - | expression tag |
| Tyr 14 | - | expression tag |
| Lys 15 | - | expression tag |
| Asp 16 | - | expression tag |
| Asp 17 | - | expression tag |
| Asp 18 | - | expression tag |
| Asp 19 | - | expression tag |
| Lys 20 | - | expression tag |
| Gly 21 | - | expression tag |
| Thr 22 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 227336.6 | |
| All* | Total formula weight | 227336.6 |
