22GC
The structure of HER2-m66-trastuzumab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Trastuzumab FAB LIGHT CHAIN | polymer | 237 | 26131.2 | 1 | Homo sapiens | ||
| 2 | B (G) | m66 (murine-derived) HEAVY CHAIN, | polymer | 238 | 25910.0 | 1 | Mus musculus | ||
| 3 | C (A) | Receptor tyrosine-protein kinase erbB-2 | polymer | 357 | 39562.8 | 1 | UniProt (P04626) Pfam (PF01030) Pfam (PF14843) | Homo sapiens (human) | Metastatic lymph node gene 19 protein,MLN 19,Proto-oncogene Neu,Proto-oncogene c-ErbB-2,Tyrosine kinase-type cell surface receptor HER2,p185erbB2 |
| 4 | D (D) | m66 (murine-derived) HEAVY CHAIN, | polymer | 237 | 26134.1 | 1 | Homo sapiens | ||
| 5 | E (E) | Trastuzumab FAB HEAVY CHAIN | polymer | 237 | 25612.5 | 1 | Homo sapiens (human) | ||
| 6 | F (C) | Receptor tyrosine-protein kinase erbB-2 | polymer | 308 | 33829.4 | 1 | UniProt (P04626) Pfam (PF01030) Pfam (PF00757) | Homo sapiens (human) | Metastatic lymph node gene 19 protein,MLN 19,Proto-oncogene Neu,Proto-oncogene c-ErbB-2,Tyrosine kinase-type cell surface receptor HER2,p185erbB2 |
Sequence modifications
A: 297 - 652 (UniProt: P04626)
C: 23 - 296 (UniProt: P04626)
| PDB | External Database | Details |
|---|---|---|
| End 653 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -11 | - | expression tag |
| Pro -10 | - | expression tag |
| Gly -9 | - | expression tag |
| Gly -8 | - | expression tag |
| Ser -7 | - | expression tag |
| Arg -6 | - | expression tag |
| Gly -5 | - | expression tag |
| Val -4 | - | expression tag |
| Pro -3 | - | expression tag |
| His -2 | - | expression tag |
| Ile -1 | - | expression tag |
| Val 0 | - | expression tag |
| Met 1 | - | expression tag |
| Val 2 | - | expression tag |
| Asp 3 | - | expression tag |
| Ala 4 | - | expression tag |
| Tyr 5 | - | expression tag |
| Lys 6 | - | expression tag |
| Arg 7 | - | expression tag |
| Tyr 8 | - | expression tag |
| Lys 9 | - | expression tag |
| Gly 10 | - | expression tag |
| Gly 11 | - | expression tag |
| Ser 12 | - | expression tag |
| Asp 13 | - | expression tag |
| Tyr 14 | - | expression tag |
| Lys 15 | - | expression tag |
| Asp 16 | - | expression tag |
| Asp 17 | - | expression tag |
| Asp 18 | - | expression tag |
| Asp 19 | - | expression tag |
| Lys 20 | - | expression tag |
| Gly 21 | - | expression tag |
| Thr 22 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 177180.0 | |
| All* | Total formula weight | 177180.0 |
