22EA

Cryo-EM structure of MERS-CoV S protein bound with receptor DPP4 in the conformation 3 (3 up RBD and 3 DPP4 bound).

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, D, E, G... (D, E, F, G, A...)	Dipeptidyl peptidase 4 membrane form	polymer	791	91249.2	6	UniProt (P27487)	Homo sapiens (human)	Dipeptidyl peptidase IV membrane form
2	C, F, I (H, I, C)	Spike glycoprotein	polymer	1340	147846.6	3	UniProt (K9N5Q8)	Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (MERS-CoV Betacoronavirus England 1)	S glycoprotein,E2,Peplomer protein

Sequence modifications

D, E, F, G, A, B: 29 - 766 (UniProt: P27487)

PDB	External Database	Details
Met -14	-	initiating methionine
Leu -13	-	expression tag
Leu -12	-	expression tag
Val -11	-	expression tag
Asn -10	-	expression tag
Gln -9	-	expression tag
Ser -8	-	expression tag
His -7	-	expression tag
Gln -6	-	expression tag
Gly -5	-	expression tag
Phe -4	-	expression tag
Asn -3	-	expression tag
Lys -2	-	expression tag
Glu -1	-	expression tag
His 0	-	expression tag
Thr 1	-	expression tag
Ser 2	-	expression tag
Lys 3	-	expression tag
Met 4	-	expression tag
Val 5	-	expression tag
Ser 6	-	expression tag
Ala 7	-	expression tag
Ile 8	-	expression tag
Val 9	-	expression tag
Leu 10	-	expression tag
Tyr 11	-	expression tag
Val 12	-	expression tag
Leu 13	-	expression tag
Leu 14	-	expression tag
Ala 15	-	expression tag
Ala 16	-	expression tag
Ala 17	-	expression tag
Ala 18	-	expression tag
His 19	-	expression tag
Ser 20	-	expression tag
Ala 21	-	expression tag
Phe 22	-	expression tag
Ala 23	-	expression tag
Ala 24	-	expression tag
Asp 25	-	expression tag
Met 26	-	expression tag
Gly 27	-	expression tag
Ser 28	-	expression tag
Gly 767	-	expression tag
Ser 768	-	expression tag
His 769	-	expression tag
His 770	-	expression tag
His 771	-	expression tag
His 772	-	expression tag
His 773	-	expression tag
His 774	-	expression tag
His 775	-	expression tag
His 776	-	expression tag

H, I, C: 1 - 1291 (UniProt: K9N5Q8)

PDB	External Database	Details
Gly 1292	-	expression tag
Ser 1293	-	expression tag
Gly 1294	-	expression tag
Tyr 1295	-	expression tag
Ile 1296	-	expression tag
Pro 1297	-	expression tag
Glu 1298	-	expression tag
Ala 1299	-	expression tag
Pro 1300	-	expression tag
Arg 1301	-	expression tag
Asp 1302	-	expression tag
Gly 1303	-	expression tag
Gln 1304	-	expression tag
Ala 1305	-	expression tag
Tyr 1306	-	expression tag
Val 1307	-	expression tag
Arg 1308	-	expression tag
Lys 1309	-	expression tag
Asp 1310	-	expression tag
Gly 1311	-	expression tag
Glu 1312	-	expression tag
Trp 1313	-	expression tag
Val 1314	-	expression tag
Leu 1315	-	expression tag
Leu 1316	-	expression tag
Ser 1317	-	expression tag
Thr 1318	-	expression tag
Phe 1319	-	expression tag
Leu 1320	-	expression tag
Gly 1321	-	expression tag
Arg 1322	-	expression tag
Ser 1323	-	expression tag
Leu 1324	-	expression tag
Glu 1325	-	expression tag
Val 1326	-	expression tag
Leu 1327	-	expression tag
Phe 1328	-	expression tag
Gln 1329	-	expression tag
Gly 1330	-	expression tag
Pro 1331	-	expression tag
Gly 1332	-	expression tag
His 1333	-	expression tag
His 1334	-	expression tag
His 1335	-	expression tag
His 1336	-	expression tag
His 1337	-	expression tag
His 1338	-	expression tag
His 1339	-	expression tag
His 1340	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	9
	Total formula weight	991034.8
All*	Total formula weight	991034.8

*Water molecules are not included.