21WA
Cryo-EM structure of the ATPase domain of SMARCA4 bound to a nucleosome
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E (A, E) | Histone H3 | polymer | 135 | 15303.9 | 2 | UniProt (A0A310TTQ1) Pfam (PF00125) | Xenopus laevis (African clawed frog) | |
| 2 | B, F (B, F) | Histone H4 | polymer | 102 | 11263.2 | 2 | UniProt (P62799) Pfam (PF15511) | Xenopus laevis (African clawed frog) | |
| 3 | C, G (C, G) | Histone H2A | polymer | 129 | 13978.2 | 2 | UniProt (Q6AZJ8) Pfam (PF00125) Pfam (PF16211) | Xenopus laevis (African clawed frog) | |
| 4 | D, H (D, H) | Histone H2B | polymer | 125 | 13848.1 | 2 | UniProt (A0A8J0U496) Pfam (PF00125) | Xenopus laevis (African clawed frog) | |
| 5 | I (I) | SMARCA4 isoform 2 | polymer | 1711 | 191867.2 | 1 | UniProt (Q9HBD4) Pfam (PF00271) Pfam (PF14619) Pfam (PF00439) Pfam (PF08880) Pfam (PF07529) Pfam (PF07533) Pfam (PF00176) | Homo sapiens (human) | SWI/SNF related,matrix associated,actin dependent regulator of chromatin,subfamily a,member 4 |
| 6 | J (X) | DNA (167-MER) | polymer | 167 | 51333.7 | 1 | Homo sapiens (human) | ||
| 7 | K (Y) | DNA (167-MER) | polymer | 167 | 51774.0 | 1 | Homo sapiens (human) | ||
| 8 | L (I) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 9 | M (I) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 10 | N (I) | BERYLLIUM TRIFLUORIDE ION | non-polymer | 66.0 | 1 | Chemie (BEF) |
Sequence modifications
I: 1 - 1679 (UniProt: Q9HBD4)
| PDB | External Database | Details |
|---|---|---|
| Gly -9 | - | expression tag |
| Pro -8 | - | expression tag |
| Gly -7 | - | expression tag |
| Gly -6 | - | expression tag |
| Ser -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Thr 0 | - | expression tag |
| Asp 1680 | - | expression tag |
| Tyr 1681 | - | expression tag |
| Lys 1682 | - | expression tag |
| Asp 1683 | - | expression tag |
| His 1684 | - | expression tag |
| Asp 1685 | - | expression tag |
| Gly 1686 | - | expression tag |
| Asp 1687 | - | expression tag |
| Tyr 1688 | - | expression tag |
| Lys 1689 | - | expression tag |
| Asp 1690 | - | expression tag |
| His 1691 | - | expression tag |
| Asp 1692 | - | expression tag |
| Ile 1693 | - | expression tag |
| Asp 1694 | - | expression tag |
| Tyr 1695 | - | expression tag |
| Lys 1696 | - | expression tag |
| Asp 1697 | - | expression tag |
| Asp 1698 | - | expression tag |
| Asp 1699 | - | expression tag |
| Asp 1700 | - | expression tag |
| Lys 1701 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 11 |
| Total formula weight | 403761.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 517.5 | |
| All* | Total formula weight | 404279.4 |
