21FG

Cryo-EM structure of the human P2X3 receptor in the ATP- and sivopixant-bound closed state

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	P2X purinoceptor 3	polymer	327	36645.3	3	UniProt (P56373) Pfam (PF00864)	Homo sapiens (human)	P2X3,ATP receptor,Purinergic receptor
2	D, J, O (A, B, C)	Sivopixant	non-polymer		507.9	3	Chemie (A1E2N) PubChem (117752163)
3	E, F, G, K, L... (A, B, C)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	9	Chemie (NAG) PubChem (24139)
4	H, I, N (A, B)	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	3	Chemie (ATP)

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	109936.0
Non-Polymers*	Number of molecules	15
	Total formula weight	5036.2
All*	Total formula weight	114972.2

*Water molecules are not included.