21ES

Structural and Functional Insights into VEGFR-3-Mediated Lymphangiogenesis : Unraveling the clustering mechanism of VEGFR-3/VEGF-C

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, E, F)	Vascular endothelial growth factor receptor 3	polymer	778	87501.1	4	UniProt (P35916) Pfam (PF22854) Pfam (PF21339) Pfam (PF13927) Pfam (PF22971) Pfam (PF07679)	Homo sapiens (human)
2	E, F, G, H (C, D, G, H)	Vascular endothelial growth factor C	polymer	125	13814.7	4	UniProt (P49767) Pfam (PF00341)	Homo sapiens (human)

Sequence modifications

A, B, E, F: 1 - 770 (UniProt: P35916)

PDB	External Database	Details
Leu 771	-	expression tag
Lys 772	-	expression tag
Leu 773	-	expression tag
Glu 774	-	expression tag
Val 775	-	expression tag
Leu 776	-	expression tag
Phe 777	-	expression tag
Gln 778	-	expression tag

C, D, G, H: 103 - 215 (UniProt: P49767)

PDB	External Database	Details
Ser 99	-	expression tag
Gly 100	-	expression tag
Gly 101	-	expression tag
Ser 102	-	expression tag
Ala 137	Cys 137	conflict
Gly 216	-	expression tag
Ser 217	-	expression tag
His 218	-	expression tag
His 219	-	expression tag
His 220	-	expression tag
His 221	-	expression tag
His 222	-	expression tag
His 223	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	405263.1
All*	Total formula weight	405263.1

*Water molecules are not included.