21EI

Structural and Functional Insights into VEGFR-3-Mediated Lymphangiogenesis : Unraveling the clustering mechanism of VEGFR-3/VEGF-C

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, E)	Vascular endothelial growth factor receptor 3	polymer	778	87501.1	3	UniProt (P35916)	Homo sapiens (human)	VEGFR-3,Fms-like tyrosine kinase 4,FLT-4,Tyrosine-protein kinase receptor FLT4
2	D, E, F, G (D, C, H, G)	Vascular endothelial growth factor C	polymer	125	13814.7	4	UniProt (P49767)	Homo sapiens (human)	VEGF-C,Flt4 ligand,Flt4-L,Vascular endothelial growth factor-related protein,VRP

Sequence modifications

A, B, E: 1 - 770 (UniProt: P35916)

PDB	External Database	Details
Leu 771	-	expression tag
Lys 772	-	expression tag
Leu 773	-	expression tag
Glu 774	-	expression tag
Val 775	-	expression tag
Leu 776	-	expression tag
Phe 777	-	expression tag
Gln 778	-	expression tag

D, C, H, G: 103 - 215 (UniProt: P49767)

PDB	External Database	Details
Ser 99	-	expression tag
Gly 100	-	expression tag
Gly 101	-	expression tag
Ser 102	-	expression tag
Ala 137	Cys 137	engineered mutation
Gly 216	-	expression tag
Ser 217	-	expression tag
His 218	-	expression tag
His 219	-	expression tag
His 220	-	expression tag
His 221	-	expression tag
His 222	-	expression tag
His 223	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	7
	Total formula weight	317762.0
All*	Total formula weight	317762.0

*Water molecules are not included.