21CI
Crystal structure of human orexin type 2 receptor in complex with vornorexant
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Orexin receptor type 2 | polymer | 341 | 39561.9 | 1 | UniProt (O43614) Pfam (PF00001) | Homo sapiens (human) | Ox-2-R,Ox2-R,Ox2R,Hypocretin receptor type 2 |
| 2 | B (A) | vornorexant | non-polymer | 447.5 | 1 | Chemie (A1MCY) | |||
| 3 | C, D (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) |
Sequence modifications
A: 33 - 394 (UniProt: O43614)
| PDB | External Database | Details |
|---|---|---|
| Gly 29 | - | expression tag |
| Pro 30 | - | expression tag |
| Leu 31 | - | expression tag |
| Glu 32 | - | expression tag |
| Ala 100 | Asp 100 | engineered mutation |
| Trp 143 | Leu 143 | engineered mutation |
| Ala 147 | Cys 147 | engineered mutation |
| Gln 202 | Asn 202 | engineered mutation |
| - | Thr 258 | deletion |
| - | Ser 259 | deletion |
| - | Ser 260 | deletion |
| - | Val 261 | deletion |
| - | Val 262 | deletion |
| - | Gln 263 | deletion |
| - | Arg 264 | deletion |
| - | Lys 265 | deletion |
| - | Trp 266 | deletion |
| - | Lys 267 | deletion |
| - | Pro 268 | deletion |
| - | Leu 269 | deletion |
| - | Gln 270 | deletion |
| - | Pro 271 | deletion |
| - | Val 272 | deletion |
| - | Ser 273 | deletion |
| - | Gln 274 | deletion |
| - | Pro 275 | deletion |
| - | Arg 276 | deletion |
| - | Gly 277 | deletion |
| - | Pro 278 | deletion |
| - | Gly 279 | deletion |
| - | Gln 280 | deletion |
| - | Pro 281 | deletion |
| - | Thr 282 | deletion |
| - | Lys 283 | deletion |
| - | Ser 284 | deletion |
| - | Arg 285 | deletion |
| - | Met 286 | deletion |
| - | Ser 287 | deletion |
| - | Ala 288 | deletion |
| Leu 395 | - | expression tag |
| Glu 396 | - | expression tag |
| Val 397 | - | expression tag |
| Leu 398 | - | expression tag |
| Phe 399 | - | expression tag |
| Gln 400 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 39561.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 639.6 | |
| All* | Total formula weight | 40201.5 |
