1ZY4

Crystal Structure of eIF2alpha Protein Kinase GCN2: R794G Hyperactivating Mutant in Apo Form.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Serine/threonine-protein kinase GCN2	polymer	303	35043.3	2	UniProt (P15442) Pfam (PF00069)	Saccharomyces cerevisiae (baker's yeast)
2	C, D (A, B)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
3	E, F (A, B)	water	water		18.0	234	Chemie (HOH)

Sequence modifications

A, B: 594 - 664 (UniProt: P15442)

PDB	External Database	Details
Ser 592	-	cloning artifact
Leu 593	-	cloning artifact

A, B: 768 - 997 (UniProt: P15442)

PDB	External Database	Details
Gly 794	Arg 725	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	70086.7
Non-Polymers*	Number of molecules	2
	Total formula weight	184.2
All*	Total formula weight	70270.9

*Water molecules are not included.