1ZML
Crystal Structure of the Catalytic Domain of Factor XI in complex with (R)-1-(4-(4-(hydroxymethyl)-1,3,2-dioxaborolan-2-yl)phenethyl)guanidine
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Coagulation factor XI | polymer | 238 | 26752.4 | 1 | UniProt (P03951) Pfam (PF00089) In PDB | Homo sapiens (human) | Plasma thromboplastin antecedent, PTA, FXI |
2 | A | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
3 | A | BICARBONATE ION | non-polymer | 61.0 | 1 | Chemie (BCT) | |||
4 | A | (R)-1-(4-(4-(HYDROXYMETHYL)-1,3,2-DIOXABOROLAN-2-YL)PHENETHYL)GUANIDINE | non-polymer | 263.1 | 1 | Chemie (412) | |||
5 | water | water | 18.0 | 181 | Chemie (HOH) |
Sequence modifications
A: 16 - 245 (UniProt: P03951)
PDB | External Database | Details |
---|---|---|
Ala 75 | Ser 452 | engineered mutation |
Ala 78 | Lys 455 | engineered mutation |
Ala 115 | Thr 493 | engineered mutation |
Ser 123 | Cys 500 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 26752.4 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 900.5 | |
All* | Total formula weight | 27652.9 |