1Z7Q
Crystal structure of the 20s proteasome from yeast in complex with the proteasome activator PA26 from Trypanosome brucei at 3.2 angstroms resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, O (A, O) | Proteasome component C7-alpha | polymer | 252 | 28033.8 | 2 | UniProt (P21243) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae (baker's yeast) | Macropain subunit C7- alpha, Proteinase YSCE subunit 7, Multicatalytic endopeptidase complex C7, Component Y8, SCL1 suppressor protein |
| 2 | B, P (B, P) | Proteasome component Y7 | polymer | 250 | 27191.8 | 2 | UniProt (P23639) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae (baker's yeast) | Macropain subunit Y7, Proteinase YSCE subunit 7, Multicatalytic endopeptidase complex subunit Y7 |
| 3 | C, Q (C, Q) | Proteasome component Y13 | polymer | 258 | 28748.2 | 2 | UniProt (P23638) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae (baker's yeast) | Macropain subunit Y13, Proteinase YSCE subunit 13, Multicatalytic endopeptidase complex subunit Y13 |
| 4 | D, R (D, R) | Proteasome component PRE6 | polymer | 254 | 28478.1 | 2 | UniProt (P40303) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae (baker's yeast) | Macropain subunit PRE6, Proteinase YSCE subunit PRE6, Multicatalytic endopeptidase complex subunit PRE6 |
| 5 | E, S (E, S) | Proteasome component PUP2 | polymer | 260 | 28649.1 | 2 | UniProt (P32379) Pfam (PF00227) Pfam (PF10584) | Saccharomyces cerevisiae (baker's yeast) | Macropain subunit PUP2, Proteinase YSCE subunit PUP2, Multicatalytic endopeptidase complex subunit PUP2 |
| 6 | F, T (F, T) | Proteasome component PRE5 | polymer | 234 | 25634.0 | 2 | UniProt (P40302) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae (baker's yeast) | Macropain subunit PRE5, Proteinase YSCE subunit PRE5, Multicatalytic endopeptidase complex subunit PRE5 |
| 7 | G, U (G, U) | Proteasome component C1 | polymer | 288 | 31575.1 | 2 | UniProt (P21242) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae (baker's yeast) | Macropain subunit C1, Proteinase YSCE subunit 1, Multicatalytic endopeptidase complex subunit C1 |
| 8 | H, V (H, V) | Proteasome component PRE3 | polymer | 196 | 21517.2 | 2 | UniProt (P38624) Pfam (PF00227) | Saccharomyces cerevisiae (baker's yeast) | Macropain subunit PRE3, Proteinase YSCE subunit PRE3, Multicatalytic endopeptidase complex subunit PRE3 |
| 9 | I, W (I, W) | Proteasome component PUP1 | polymer | 222 | 23987.3 | 2 | UniProt (P25043) Pfam (PF00227) Pfam (PF12465) | Saccharomyces cerevisiae (baker's yeast) | Macropain subunit PUP1, Proteinase YSCE subunit PUP1, Multicatalytic endopeptidase complex subunit PUP1 |
| 10 | J, X (J, X) | Proteasome component PUP3 | polymer | 205 | 22627.8 | 2 | UniProt (P25451) Pfam (PF00227) | Saccharomyces cerevisiae (baker's yeast) | Macropain subunit PUP3, Multicatalytic endopeptidase complex subunit PUP3 |
| 11 | K, Y (K, Y) | Proteasome component C11 | polymer | 198 | 22545.7 | 2 | UniProt (P22141) Pfam (PF00227) | Saccharomyces cerevisiae (baker's yeast) | Macropain subunit C11, Proteinase YSCE subunit 11, Multicatalytic endopeptidase complex subunit C11 |
| 12 | L, Z (L, Z) | Proteasome component PRE2 | polymer | 212 | 23353.3 | 2 | UniProt (P30656) Pfam (PF00227) | Saccharomyces cerevisiae (baker's yeast) | Macropain subunit PRE2, Proteinase YSCE subunit PRE2, Multicatalytic endopeptidase complex subunit PRE2 |
| 13 | AA, M (M, a) | Potential proteasome component C5 | polymer | 222 | 24883.9 | 2 | UniProt (P23724) Pfam (PF00227) | Saccharomyces cerevisiae (baker's yeast) | Multicatalytic endopeptidase complex subunit C5 |
| 14 | BA, N (N, b) | Proteasome component PRE4 | polymer | 233 | 25945.5 | 2 | UniProt (P30657) Pfam (PF00227) | Saccharomyces cerevisiae (baker's yeast) | Macropain subunit PRE4, Proteinase YSCE subunit PRE4, Multicatalytic endopeptidase complex subunit PRE4 |
| 15 | CA, DA, EA, FA, GA... (c, d, e, f, g...) | proteasome activator protein PA26 | polymer | 231 | 25228.7 | 14 | UniProt (Q9U8G2) Pfam (PF02252) | Trypanosoma brucei |
Sequence modifications
L, Z: 1 - 212 (UniProt: P30656)
c, d, e, f, g, h, i, j, k, l, m, n, o, p: 1001 - 1231 (UniProt: Q9U8G2)
| PDB | External Database | Details |
|---|---|---|
| Arg 33 | Lys 108 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Val 1049 | Thr 49 | conflict |
| - | Ser 162 | deletion |
| Gly 1171 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 42 |
| Total formula weight | 1079543.9 | |
| All* | Total formula weight | 1079543.9 |
