1YSW
Solution structure of the anti-apoptotic protein Bcl-2 complexed with an acyl-sulfonamide-based ligand
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Apoptosis regulator Bcl-2 | polymer | 164 | 19155.3 | 1 | UniProt (P10415) Pfam (PF02180) Pfam (PF00452) | Homo sapiens (human) | |
| 2 | B (A) | 3-NITRO-N-{4-[2-(2-PHENYLETHYL)-1,3-BENZOTHIAZOL-5-YL]BENZOYL}-4-{[2-(PHENYLSULFANYL)ETHYL]AMINO}BENZENESULFONAMIDE | non-polymer | 694.8 | 1 | Chemie (43B) |
Sequence modifications
A: 1 - 32 (UniProt: P10415)
A: 89 - 203 (UniProt: P10415)
| PDB | External Database | Details |
|---|---|---|
| Asp 32 | - | insertion |
| PDB | External Database | Details |
|---|---|---|
| Asp 33 | - | insertion |
| Val 34 | - | insertion |
| Glu 35 | - | insertion |
| Glu 36 | - | insertion |
| Asn 37 | - | insertion |
| Arg 38 | - | insertion |
| Thr 39 | - | insertion |
| Glu 40 | - | insertion |
| Ala 41 | - | insertion |
| Pro 42 | - | insertion |
| Glu 43 | - | insertion |
| Gly 44 | - | insertion |
| Thr 45 | - | insertion |
| Glu 46 | - | insertion |
| Ser 47 | - | insertion |
| Glu 48 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 19155.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 694.8 | |
| All* | Total formula weight | 19850.1 |
