1YSW
Solution structure of the anti-apoptotic protein Bcl-2 complexed with an acyl-sulfonamide-based ligand
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Apoptosis regulator Bcl-2 | polymer | 164 | 19155.3 | 1 | UniProt (P10415) Pfam (PF02180) Pfam (PF00452) In PDB | Homo sapiens (human) | |
2 | A | 3-NITRO-N-{4-[2-(2-PHENYLETHYL)-1,3-BENZOTHIAZOL-5-YL]BENZOYL}-4-{[2-(PHENYLSULFANYL)ETHYL]AMINO}BENZENESULFONAMIDE | non-polymer | 694.8 | 1 | Chemie (43B) |
Sequence modifications
A: 1 - 32 (UniProt: P10415)
A: 89 - 203 (UniProt: P10415)
PDB | External Database | Details |
---|---|---|
Asp 32 | - | insertion |
PDB | External Database | Details |
---|---|---|
Asp 33 | - | insertion |
Val 34 | - | insertion |
Glu 35 | - | insertion |
Glu 36 | - | insertion |
Asn 37 | - | insertion |
Arg 38 | - | insertion |
Thr 39 | - | insertion |
Glu 40 | - | insertion |
Ala 41 | - | insertion |
Pro 42 | - | insertion |
Glu 43 | - | insertion |
Gly 44 | - | insertion |
Thr 45 | - | insertion |
Glu 46 | - | insertion |
Ser 47 | - | insertion |
Glu 48 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 19155.3 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 694.8 | |
All* | Total formula weight | 19850.1 |