1YSW

Solution structure of the anti-apoptotic protein Bcl-2 complexed with an acyl-sulfonamide-based ligand

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Apoptosis regulator Bcl-2	polymer	164	19155.3	1	UniProt (P10415) Pfam (PF02180) Pfam (PF00452) In PDB	Homo sapiens (human)
2	A	3-NITRO-N-{4-[2-(2-PHENYLETHYL)-1,3-BENZOTHIAZOL-5-YL]BENZOYL}-4-{[2-(PHENYLSULFANYL)ETHYL]AMINO}BENZENESULFONAMIDE	non-polymer		694.8	1	Chemie (43B)

Sequence modifications

A: 1 - 32 (UniProt: P10415)

PDB	External Database	Details
Asp 32	-	insertion

A: 89 - 203 (UniProt: P10415)

PDB	External Database	Details
Asp 33	-	insertion
Val 34	-	insertion
Glu 35	-	insertion
Glu 36	-	insertion
Asn 37	-	insertion
Arg 38	-	insertion
Thr 39	-	insertion
Glu 40	-	insertion
Ala 41	-	insertion
Pro 42	-	insertion
Glu 43	-	insertion
Gly 44	-	insertion
Thr 45	-	insertion
Glu 46	-	insertion
Ser 47	-	insertion
Glu 48	-	insertion

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	19155.3
Non-Polymers*	Number of molecules	1
	Total formula weight	694.8
All*	Total formula weight	19850.1

*Water molecules are not included.